Subunit Blood-Stage Malaria Vaccines

Malaria ◽  
2017 ◽  
pp. 211-238
Author(s):  
Alexander D. Douglas
Keyword(s):  
Blood Stage ◽  
Malaria Vaccines ◽  
Blood Stage Malaria

scholarly journals ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

2012 ◽  
Vol 20 (12) ◽  
pp. 2355-2368 ◽  
Author(s):  
Susanne H Sheehy ◽  
Christopher JA Duncan ◽  
Sean C Elias ◽  
Prateek Choudhary ◽  
Sumi Biswas ◽  
...  
Keyword(s):  
Blood Stage ◽  
Mosquito Bite ◽  
Malaria Vaccines ◽  
Blood Stage Malaria

Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates

2017 ◽  
Vol 16 (8) ◽  
pp. 769-779 ◽  
Author(s):  
Edward H. Ntege ◽  
Eizo Takashima ◽  
Masayuki Morita ◽  
Hikaru Nagaoka ◽  
Tomoko Ishino ◽  
...  
Keyword(s):  
Blood Stage ◽  
Vaccine Candidates ◽  
Malaria Vaccines ◽  
Blood Stage Malaria

scholarly journals A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

2021 ◽  
Author(s):  
Lucie Jelinkova ◽  
Yevel Flores-Garcia ◽  
Sarah Shapiro ◽  
Bryce T Roberts ◽  
Nikolai Petrovsky ◽  
...  
Keyword(s):  
High Titer ◽  
Antibody Responses ◽  
Circumsporozoite Protein ◽  
Blood Stage ◽  
Infection Model ◽  
Malaria Vaccines ◽  
Mouse Infection Model ◽  
Virus Like Particle ◽  
Blood Stage Infection ◽  
Blood Stage Malaria

Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) that is recognized by the potently inhibitory monoclonal antibody L9 and show that immunization with L9 VLPs induces strong antibody responses that provide protection from blood-stage malaria in a mouse infection model.

scholarly journals Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

2012 ◽  
Vol 206 (3) ◽  
pp. 319-323 ◽  
Author(s):  
M. Roestenberg ◽  
S. J. de Vlas ◽  
A.-E. Nieman ◽  
R. W. Sauerwein ◽  
C. C. Hermsen
Keyword(s):  
Blood Stage ◽  
Malaria Vaccines ◽  
Human Volunteers ◽  
Blood Stage Malaria

Immune Responses to Whole-Organism Blood-Stage Malaria Vaccines

Malaria ◽  
2017 ◽  
pp. 197-210
Author(s):  
Amber I. Raja ◽  
Danielle I. Stanisic ◽  
Michael F. Good
Keyword(s):  
Immune Responses ◽  
Blood Stage ◽  
Malaria Vaccines ◽  
Blood Stage Malaria
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