Current Concepts on Bilirubin Metabolism and Gilbert’s Syndrome

1983 ◽  
pp. 70-77
Author(s):  
L. Okolicsanyi
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Bilirubin Metabolism

How dangerous Gilbert's syndrome is

2021 ◽  
pp. 8-12
Author(s):  
Roman Petrovich Stepchenkov
Keyword(s):  
Pathological Condition ◽  
Inhibitory Effect ◽  
Unconjugated Bilirubin ◽  
Breakdown Product ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Bilirubin Metabolism ◽  
Gallbladder Dyskinesia ◽  
Conjugation Process ◽  
Loss Of Appetite

Gilbert's syndrome is a benign (functional) hyperbilirubinemia, which is based on a hereditary disorder of bilirubin metabolism, as a result of which the concentration of unbound bilirubin can increase several times. Bilirubin, being a breakdown product of hemoglobin, circulates through the bloodstream, combining with albumin molecules. Such bilirubin is called indirect. In the endoplasmic reticulum, it is conjugated; the enzyme glucuronyltransferase is responsible for this process. In Gilbert's syndrome, as a result of insufficient production of this enzyme, the conjugation process is disrupted, and, as a result, the concentration of unconjugated bilirubin increases. According to statistics, this pathological condition is observed in about 5 % of Russians. This syndrome was first described in 1901 by the French physician Augustin Nicolas Gilbert, and was subsequently named after him. The literature also contains references to this syndrome, described as «constitutional hepatic dysfunction», «familial non-hemolytic hyperbilirubinemia», «idiopathic non-conjugated hyperbilirubinemia». Gilbert's syndrome is inherited in an autosomal recessive manner; men get ill 3–4 times more often than women. A number of scientists associate this with a possible inhibitory effect of testosterone on the enzyme UDP-GT1, which breaks down bilirubin. Clinically, Gilbert's syndrome is manifested by episodes of jaundice caused by an increase in the level of unconjugated bilirubin in the blood serum. Against the background of icterus of the sclera and skin, there is increased fatigue, the appearance of a feeling of bitterness in the mouth, loss of appetite, nausea, and sometimes vomiting. The association of Gilbert's syndrome with functional disorders of the biliary tract, in particular, with gallbladder dyskinesia, is often noted.

Effects of corticosteroids on bilirubin metabolism in patients with Gilbert's syndrome

Hepatology ◽  
1981 ◽  
Vol 1 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Hideki Ohkubo ◽  
Kunio Okuda ◽  
Shinji Iida
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Bilirubin Metabolism

A familial Mediterranean fever girl due to MEFV N679H mutation with Gilbert’s syndrome

2021 ◽  
Author(s):  
Yuki Fujimaki ◽  
Takehiko Soutome ◽  
Takayuki Tanaka ◽  
Takeshi Shiba ◽  
Misa Watanabe
Keyword(s):  
Familial Mediterranean Fever ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Mediterranean Fever

A Case of Acquired Gilbert’s Syndrome

2016 ◽  
Vol 56 (12) ◽  
pp. 1164-1166
Author(s):  
Jonathan Leong ◽  
Maria-Stella Serrano
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

Predicted homozygous mis-sense mutation in Gilbert's syndrome

The Lancet ◽  
1995 ◽  
Vol 346 (8988) ◽  
pp. 1494 ◽  
Author(s):  
Yoko Soeda ◽  
Kazuo Yamamoto ◽  
Yukihiko Adachi ◽  
Takeshi Hori ◽  
Sachiko Aono ◽  
...  
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE

The Lancet ◽  
1970 ◽  
Vol 295 (7661) ◽  
pp. 1359-1362 ◽  
Author(s):  
Martin Black ◽  
Sheila Sherlock
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

Isotretinoin usage particularities in acne therapy in patients with Gilbert’s syndrome

2021 ◽  
Vol 20 (3) ◽  
pp. 53
Author(s):  
E.S. Negasheva ◽  
D.A. Blinova ◽  
M.S. Kornyat ◽  
S.A. Polevshchikova ◽  
N.F. Zatorskaya ◽  
...  
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome ◽  
Acne Therapy

scholarly journals A case of concomitant Gilbert's syndrome and hereditary spherocytosis

2010 ◽  
Vol 16 (3) ◽  
pp. 321 ◽  
Author(s):  
Hee Jung Lee ◽  
Hee Seok Moon ◽  
Eaum Seok Lee ◽  
Seok Hyun Kim ◽  
Jae Kyu Sung ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

scholarly journals A Case of Hereditary Spherocytosis Coexisting with Gilbert's Syndrome

2013 ◽  
Vol 61 (3) ◽  
pp. 166 ◽  
Author(s):  
Min-Jae Lee ◽  
Yoon Hwan Chang ◽  
Seung-Hwa Kang ◽  
Se-Kwon Mun ◽  
Heyjin Kim ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome

Impaired bilitranslocase (BTL) function in Gilbert's syndrome

1989 ◽  
Vol 9 ◽  
pp. S204
Author(s):  
M. Persico ◽  
C. Tiribelli ◽  
S. Gentile ◽  
M. Coltorti
Keyword(s):  
Gilbert’S Syndrome ◽  
Gilbert's Syndrome
Sign in / Sign up

Export Citation Format

Share Document