Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds

1986 ◽  
Keyword(s):  
Sterol Biosynthesis ◽  
Biosynthesis Inhibitors

The Effects of Sterol Biosynthesis Inhibitors on Cleavage in Allomyces macrogynus

Mycologia ◽  
1988 ◽  
Vol 80 (5) ◽  
pp. 716 ◽  
Author(s):  
Melvin S. Fuller ◽  
Robert W. Roberson
Keyword(s):  
Sterol Biosynthesis ◽  
Allomyces Macrogynus ◽  
Biosynthesis Inhibitors

scholarly journals Sensitivity to Sterol Biosynthesis Inhibitors of Colletotrichum gloeosporioides Isolated from Persimmon in 2013 in Sangju, Gyeongsangbukdo

2015 ◽  
Vol 19 (3) ◽  
pp. 272-278 ◽  
Author(s):  
Tae Heon Lim ◽  
Dong Woon Lee ◽  
Oh Gyeong Kwon ◽  
Sangsub Han ◽  
Byeongjin Cha ◽  
...  
Keyword(s):  
Colletotrichum Gloeosporioides ◽  
Sterol Biosynthesis ◽  
Biosynthesis Inhibitors

Lipid biosynthesis pathways as chemotherapeutic targets in kinetoplastid parasites

Parasitology ◽  
1997 ◽  
Vol 114 (7) ◽  
pp. 91-99 ◽  
Author(s):  
J. A. URBINA
Keyword(s):  
Trypanosoma Cruzi ◽  
Recent Work ◽  
Chagas Disease ◽  
Pneumocystis Carinii ◽  
Lipid Biosynthesis ◽  
Sterol Biosynthesis ◽  
Leishmania Braziliensis ◽  
Biosynthesis Inhibitors

Inhibitors of sterol and phospholipid biosynthesis in kinetoplastid parasites such as Trypanosoma cruzi, the causative agent of Chagas' disease, and different species of Leishmania have potent and selective activity as chemotherapeutic agents in vitro and in vivo. Recent work with the sterol C14α-demethylase inhibitor D0870, a bis triazole derivative, showed that this compound is capable of inducing radical parasitological cure in murine models of both acute and chronic Chagas' disease. Other inhibitors of this type, such as SCH 56592, have also shown curative, rather than suppressive, activity against T. cruzi in these models. Leishmania species have different susceptibilities to sterol biosynthesis inhibitors, both in vitro and in vivo. Leishmania braziliensis promastigotes, naturally resistant to C14α-demethylase inhibitors such as ketoconazole and D0870, were susceptible to these drugs when used in combination with the squalene epoxidase inhibitor terbinafine. Inhibitors of Δ24(25) sterol methyl transferase have been shown to act as potent antiproliferative agents against Trypanosoma cruzi, both in vitro and in vivo. New inhibitors of this type which show enhanced activity and novel mechanisms of action have been synthesized. Recent work has also demonstrated that this type of enzyme inhibitors can block sterol biosynthesis and cell proliferation in Pneumocystis carinii, a fungal pathogen which had previously been found resistant to other sterol biosynthesis inhibitors. Ajoene, an antiplatelet compound derived from garlic, was shown to have potent antiproliferative activity against epimastigotes and amastigotes of Trypanosoma cruzi in vitro; this activity was associated with a significant alteration of the phospholipid composition of the cells with no significant effects on the sterol content. In addition, alkyllsophospholipids such as ilmofosine, miltefosine and edelfosine have been shown to block the proliferation of T. cruzi and Leishmania and alter both the phospholipid and sterol composition. These results indicate the potential of lipid biosynthesis inhibitors as useful therapeutic agents in the treatment of leishmaniasis and Chagas' disease.

scholarly journals Characterization ofFEN1gene involved in sensitivity to Sterol Biosynthesis Inhibitors inSaccharomyces cerevisiae

1999 ◽  
Vol 146 (1) ◽  
pp. 67-72
Author(s):  
Johann Joets ◽  
Isabelle Soustre ◽  
Rachida Kribii ◽  
Didier Delourme ◽  
Francis Karst
Keyword(s):  
Sterol Biosynthesis ◽  
Biosynthesis Inhibitors

Control of Dutch elm disease by the sterol biosynthesis inhibitors fenpropimorph and fenpropidin

1988 ◽  
Vol 94 (3) ◽  
pp. 161-173 ◽  
Author(s):  
R. J. Scheffer ◽  
A. C. Brakenhoff ◽  
A. Kerkenaar ◽  
D. M. Elgersma
Keyword(s):  
Sterol Biosynthesis ◽  
Dutch Elm Disease ◽  
Biosynthesis Inhibitors

Sterol Biosynthesis Inhibitors*

2019 ◽  
pp. 797-844 ◽  
Author(s):  
Klaus Stenzel ◽  
Jean-Pierre Vors
Keyword(s):  
Sterol Biosynthesis ◽  
Biosynthesis Inhibitors

General resistance to sterol biosynthesis inhibitors inSaccharomyces cerevisiae

Lipids ◽  
1993 ◽  
Vol 28 (10) ◽  
pp. 907-912 ◽  
Author(s):  
Véronique Ladevèze ◽  
Christophe Marcireau ◽  
Didier Delourme ◽  
Francis Karst
Keyword(s):  
Sterol Biosynthesis ◽  
General Resistance ◽  
Biosynthesis Inhibitors
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