Efficient identification of marker chromosomes in 27 patients by stepwise hybridization with alpha-satellite DNA probes

1993 ◽  
Vol 91 (2) ◽  
Author(s):  
Rina Plattner ◽  
NylaA. Heerema ◽  
YuriB. Yurov ◽  
CatherineG. Palmer
Keyword(s):  
Satellite Dna ◽  
Dna Probes ◽  
Alpha Satellite ◽  
Marker Chromosomes ◽  
Alpha Satellite Dna

Detection of monosomy in interphase nuclei and identification of marker chromosomes using biotinylated alpha-satellite DNA probes

1991 ◽  
Vol 51 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Marion Kiechle-Schwarz ◽  
Hans-Joachim H. Deckr ◽  
Carol S. Berger ◽  
Heiner H. Fiebig ◽  
Avery A. Sandberg
Keyword(s):  
Satellite Dna ◽  
Dna Probes ◽  
Alpha Satellite ◽  
Interphase Nuclei ◽  
Marker Chromosomes ◽  
Alpha Satellite Dna

Identification of the origin of ring/marker chromosomes in patients with ullrich-turner syndrome using X and Y specific alpha satellite DNA probes

1992 ◽  
Vol 42 (5) ◽  
pp. 720-723 ◽  
Author(s):  
Sugandhi A. Tharapel ◽  
R. Sid Wilroy ◽  
Amber M. Keath ◽  
Marian L. Rivas ◽  
Avirachan T. Tharapel
Keyword(s):  
Turner Syndrome ◽  
Satellite Dna ◽  
Dna Probes ◽  
Alpha Satellite ◽  
Marker Chromosomes ◽  
Alpha Satellite Dna

On the mode of evolution of alpha satellite DNA in human populations

1991 ◽  
Vol 33 (1) ◽  
pp. 42-48 ◽  
Author(s):  
B. Marçais ◽  
J. P. Charlieu ◽  
B. Allain ◽  
E. Brun ◽  
M. Bellis ◽  
...  
Keyword(s):  
Satellite Dna ◽  
Human Populations ◽  
Alpha Satellite ◽  
Alpha Satellite Dna

scholarly journals Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement.

1990 ◽  
Vol 10 (12) ◽  
pp. 6374-6380 ◽  
Author(s):  
R Wevrick ◽  
W C Earnshaw ◽  
P N Howard-Peebles ◽  
H F Willard
Keyword(s):  
Human Chromosome ◽  
Satellite Dna ◽  
Centromeric Region ◽  
Chromosome Rearrangement ◽  
Specific Antigen ◽  
Chromosome 17 ◽  
Alpha Satellite ◽  
Protein Antigens ◽  
Alpha Satellite Dna ◽  
Human Chromosome 17

A familial, constitutionally rearranged human chromosome 17 is deleted for much of the DNA in its centromeric region but retains full mitotic centromere activity. Fluorescence in situ hybridization, pulsed-field gel electrophoresis, and Southern blot analysis of the residual centromeric region revealed a approximately 700-kb centromeric array of tandemly repeated alpha satellite DNA that was only approximately 20 to 30% as large as a normal array. This deletion was associated with a reduction in the amount of the centromere-specific antigen CENP-B detected by indirect immunofluorescence. The coincidence of the primary constriction, the small residual array of alpha satellite DNA, and the reduced amount of detectable CENP-B support the hypothesis that CENP-B is associated with alpha satellite DNA. Furthermore, the finding that both the deleted chromosome 17 and its derivative supernumerary fragment retained mitotic function and possess centromeric protein antigens suggests that human centromeres are structurally and functionally repetitive.

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