Empirical comparison of the MEG and EEG: Animal models of the direct cortical response and epileptiform activity in neocortex

1991 ◽  
Vol 4 (2) ◽  
pp. 85-93 ◽  
Author(s):  
Daniel S. Barth
Keyword(s):  
Animal Models ◽  
Epileptiform Activity ◽  
Cortical Response ◽  
Empirical Comparison ◽  
Direct Cortical Response

Occlusive behavior of negative-wave direct cortical response (DCR) and single cells in the cortex.

1971 ◽  
Vol 34 (3) ◽  
pp. 374-388 ◽  
Author(s):  
J W Phillis ◽  
S Ochs
Keyword(s):  
Single Cells ◽  
Cortical Response ◽  
Negative Wave ◽  
Direct Cortical Response

Glial origin of the slow negative potential of the direct cortical response: Microelectrode study and mathematical analysis

1982 ◽  
Vol 14 (1) ◽  
pp. 63-70
Author(s):  
A. I. Roitbak ◽  
V. V. Fanardzhyan ◽  
D. S. Melkonyan ◽  
A. A. Melkonyan
Keyword(s):  
Mathematical Analysis ◽  
Negative Potential ◽  
Cortical Response ◽  
Direct Cortical Response ◽  
Slow Negative Potential

Patterns of unit discharge associated with direct cortical response in monkey and cat

1963 ◽  
Vol 15 (5) ◽  
pp. 882-888 ◽  
Author(s):  
Paul E. Stohr ◽  
Sidney Goldring ◽  
James L. O'Leary
Keyword(s):  
Cortical Response ◽  
Unit Discharge ◽  
Direct Cortical Response

scholarly journals SLOW AND SPIKE COMPONENTS OF THE DIRECT CORTICAL RESPONSE IN THE CEREBRAL CORTEX

1961 ◽  
Vol 11 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Yoshihiko IWASE ◽  
Takashi UCHIDA ◽  
Junzo OCHI
Keyword(s):  
Cerebral Cortex ◽  
Cortical Response ◽  
Direct Cortical Response

Origin of slow negative potential of direct cortical response in cats

1984 ◽  
Vol 15 (3) ◽  
pp. 234-240
Author(s):  
V. M. Okudzhava ◽  
I. A. Mzhaviya ◽  
V. G. Goff
Keyword(s):  
Negative Potential ◽  
Cortical Response ◽  
Direct Cortical Response ◽  
Slow Negative Potential

Layer I Ectopias and Increased Excitability in Murine Neocortex

2002 ◽  
Vol 87 (5) ◽  
pp. 2471-2479 ◽  
Author(s):  
Lisa A. Gabel ◽  
Joseph J. LoTurco
Keyword(s):  
Animal Models ◽  
Cognitive Impairments ◽  
Epileptiform Activity ◽  
Brain Slices ◽  
Inbred Lines ◽  
Seizure Susceptibility ◽  
Cortical Dysplasias ◽  
Layer I

Cortical dysplasias are associated with both epilepsy and cognitive impairments in humans. Similarly, several animal models of cortical dysplasia show that dysplasia causes increased seizure susceptibility and behavioral deficits in vivo and increased levels of excitability in vitro. As most current animal models involve either global disruptions in cortical architecture or the induction of lesions, it is not yet clear whether small spontaneous neocortical malformations are also associated with increased excitability or seizure susceptibility. Small groups of displaced neurons in layer I of the neocortex, ectopias, have been identified in patients with cognitive impairments, and similar malformations occur sporadically in some inbred lines of mice where they are associated with behavioral and sensory-processing deficits. In a previous study, we characterized the physiology of cells within neocortical ectopias, in one of the inbred lines (NXSM-D/Ei) and showed that the presence of multiple ectopias is associated with the generation of spontaneous epileptiform activity in slices. In this study, we use extracellular recordings from brain slices to show that even single-layer I ectopias are associated with higher excitability. Specifically, slices that contain single ectopias display epileptiform activity at significantly lower concentrations of the GABAA receptor antagonist bicuculline than do slices without ectopias (either from opposite hemispheres or animals without ectopias). Moreover, because removal of ectopias from slices does not restore normal excitability, enhanced excitability is not generated within the ectopia. Finally, we show that in vivo, mice with ectopias are more sensitive to the convulsant pentylenetetrazole than are mice without ectopias. Together these results suggest that alterations in cortical hemispheres containing focal layer I malformations increase cortical excitability and that even moderately small spontaneous cortical dysplasias are associated with increased excitability in vitro and in vivo.

The effect of experimental ischaemia on the direct cortical response of the motor cortex in primates

1988 ◽  
Vol 71 (4) ◽  
pp. 304-309 ◽  
Author(s):  
Fumiyuki Momma ◽  
H. Ian Sabin ◽  
Neil M. Branston ◽  
Lindsay Symon
Keyword(s):  
Motor Cortex ◽  
Cortical Response ◽  
Direct Cortical Response

Effect of visual deafferentation on the direct cortical response

1969 ◽  
Vol 3 (3) ◽  
pp. 91-98
Author(s):  
N. N. Zislina ◽  
N. A. Arkhipova
Keyword(s):  
Cortical Response ◽  
Direct Cortical Response ◽  
Visual Deafferentation

Regional features of background electrical activity and of direct cortical response by the intact or neuronally isolated cortex

1971 ◽  
Vol 2 (1) ◽  
pp. 40-45
Author(s):  
M. M. Khananashvili ◽  
M. M. Bogoslovskii ◽  
�. G. Zarkeshev
Keyword(s):  
Electrical Activity ◽  
Cortical Response ◽  
Regional Features ◽  
Direct Cortical Response ◽  
Isolated Cortex
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