Variable atrioventricular block in systemic lupus erythematosus

2004 ◽  
Vol 24 (2) ◽  
pp. 162-165 ◽  
Author(s):  
Sybille Liautaud ◽  
Ahmed J. Khan ◽  
Shireesha R. Nalamasu ◽  
Irene J. Tan ◽  
Anekwe E. Onwuanyi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Complete atrioventricular block in a woman with systemic lupus erythematosus

2002 ◽  
Vol 82 (3) ◽  
pp. 289-292 ◽  
Author(s):  
José Javier Gómez-Barrado ◽  
Juan Carlos Garcı́a-Rubira ◽  
Miguel Angel Polo Ostáriz ◽  
Soledad Turégano Albarrán
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Complete Atrioventricular Block ◽  
Systemic Lupus ◽  
Complete Atrioventricular

scholarly journals Neonatal Lupus and Complete Atrioventricular Block: Case Report in Mexico

2021 ◽  
pp. 1-7
Author(s):  
Carla Eugenia Arenas Alvarez ◽  
Juan Carlos Marin Mireles ◽  
Hebert Israel Flores Leal ◽  
Ana Norma Griselda Becerril Gonzalez ◽  
Carlos Mario Guzman Sanchez
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Gestational Age ◽  
Lupus Erythematosus ◽  
Fetal Echocardiography ◽  
Fetal Mortality ◽  
Complete Atrioventricular Block ◽  
Systemic Lupus ◽  
Neonatal Lupus ◽  
Complete Atrioventricular

Aims: To describe a case of neonatal lupus and complete atrioventricular block in Mexico. Presentation of case: A 38 years old pregnant patient at  28 + 6 weeks of gestational age, diagnosed with systemic lupus erythematosus six years ago, under treatment with hydroxychloroquine and prednisone, this was suspended eight months prior to pregnancy; and resumed at week 20 of gestational age. The ultrasound scan showed alive fetus, female, polyhydramnios and bradycardia. Fetal echocardiography confirmed complete atrioventricular block, without organic and structural alterations at the cardiac level. Furthermore, the immunological panel reports, positive anti-Ro antibodies. At week 33 of gestational age, the patient was admitted to the obstetric emergency room, through colic type pain and 4 cm dilation of the cervix. Alive newborn got vaginally with a weight of 1,990 g, a height of 43 cm and APGAR 8-9. Echocardiography confirmed congenital complete third degree atrioventricular block; without structural abnormalities. Discussion: Patients with systemic lupus erythematosus, are more likely to have complications during pregnancy. Neonatal lupus is a rare disorder with an incidence of 1:10,000 - 1:20,000 newborns. This is caused by the transplacental passage of maternal autoantibodies anti-SSA / Ro and/or anti-SSB / La. Besides Atrioventricular block is a complication of neonatal lupus, occurring in approximately 2% of newborns of mothers who have SSA or SSB antibodies. The most interesting finding is that 20% fetal mortality has been for this cause. Conclusion: The described case is important for its rarity. Besides, the imaging findings and immunological panel emphasized the relevance about complete and adequate evaluation of the fetus, in the context of a mother with systemic lupus erythematosus.

Severe brady-arrhythmias in systemic lupus erythematosus: prevalence, etiology and associated factors

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1415-1423 ◽  
Author(s):  
K Tselios ◽  
D D Gladman ◽  
P Harvey ◽  
J Su ◽  
M B Urowitz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Disease Duration ◽  
Systemic Lupus ◽  
Bundle Branch Block ◽  
Potential Risk Factors ◽  
Septal Hypertrophy ◽  
Artery Disease ◽  
Echocardiographic Findings

Background Severe brady-arrhythmias, requiring a permanent pacemaker (PPM), have been sparsely reported in systemic lupus erythematosus (SLE). The aim of this study was to describe the characteristics of such arrhythmias in a defined lupus cohort. Patients and methods The database of the Toronto Lupus Clinic ( n = 1366) was searched for patients who received a PPM. Demographic, clinical, immunological and therapeutic variables along with electrocardiographic (ECG) and echocardiographic findings (based on the last available test prior to PPM) were analyzed. Patients with a PPM (cases) were compared with age-, sex- and disease duration-matched patients without a PPM (controls). Analysis was performed with SAS 9.0; p < 0.05 was considered significant. Results Eighteen patients were identified, 13 (0.95%) with complete atrioventricular block and 5 (0.37%) with sick sinus syndrome. Disease duration at PPM implantation was 22 ± 12 years. Compared to controls, cases had more frequently coronary artery disease, hypertension, dyslipidemia and longer antimalarial (AM) treatment duration. The prevalence of first-degree atrioventricular block, right bundle branch block, left anterior fascicular block and septal hypertrophy was also higher. AM treatment was significantly associated with brady-arrhythmias (OR = 1.128, 95% CI = 1.003–1.267, p = 0.044). Nine patients had prior heart disease and one received a PPM two years after renal transplantation. Eight patients did not have any potential risk factors; prolonged AM therapy (mean 22 years) might have been the cause. Conclusions Apart from known causes, prolonged AM treatment may be associated with severe brady-arrhythmias in SLE. Certain ECG and echocardiographic characteristics may represent indicators of an ongoing damage in the conduction system.

First-degree atrioventricular block: A rare manifestation in systemic lupus erythematosus

2018 ◽  
Vol 02 (02) ◽  
Author(s):  
Bahloul E ◽  
Turki H ◽  
Jallouli M ◽  
Cherif Y ◽  
Garbaa S ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Rare Manifestation

Conduction system in systemic lupus erythematosus with atrioventricular block

1975 ◽  
Vol 35 (2) ◽  
pp. 299-304 ◽  
Author(s):  
Saroja Bharati ◽  
Domingo J. de la Fuente ◽  
Ronald J. Kallen ◽  
Yaser Freij ◽  
Maurice Lev
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Conduction System ◽  
Systemic Lupus

scholarly journals Hydroxychloroquine-induced Atrioventricular Block in a Patient with Systemic Lupus Erythematosus: A Case Report

2018 ◽  
Vol 44 (3) ◽  
pp. 141-146
Author(s):  
Masato Hamabashiri ◽  
Yukari Ono ◽  
Yuki Yasutaka ◽  
Susumu Kaneshige ◽  
Kentaro Ogata ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Atrioventricular Block ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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