Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system—I

1973 ◽  
Vol 22 (9) ◽  
pp. 1005-1014 ◽  
Author(s):  
Johnnie R. Hayes ◽  
Marcel U.K. Mgbodile ◽  
T.Colin Campbell
Keyword(s):  
Enzyme System ◽  
Protein Deficiency ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals Studies on Metabolism and Disposition of Sizofiran (SPG), an Anti-tumor Polysaccharide. II. Effects on Hepatic Drug-Metabolizing Enzyme System in Rats

1990 ◽  
Vol 110 (2) ◽  
pp. 159-162
Author(s):  
Shohji TANJI ◽  
Kazuo AKIMA ◽  
Minoru YOSHIOKA ◽  
Kazuo NOMURA ◽  
Masahiro HORIBA ◽  
...  
Keyword(s):  
Enzyme System ◽  
Hepatic Drug ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals ENZYME-MEMBRANE RELATIONSHIP IN PHENOBARBITAL INDUCTION OF SYNTHESIS OF DRUG-METABOLIZING ENZYME SYSTEM AND PROLIFERATION OF ENDOPLASMIC MEMBRANES

1966 ◽  
Vol 28 (2) ◽  
pp. 181-198 ◽  
Author(s):  
Sten Orrenius ◽  
Jan L. E. Ericsson
Keyword(s):  
Actinomycin D ◽  
Enzyme System ◽  
Drug Metabolizing Enzyme ◽  
Induction Process ◽  
Autophagic Activity ◽  
Metabolizing Enzyme ◽  
Parenchymal Cells ◽  
Phenobarbital Induction ◽  
Stimulation Of

The enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes has been further studied. Ultrastructural observations suggest that newly formed endoplasmic membranes in rat liver parenchymal cells arise through continuous outgrowth and budding off from pre-existing cisternae and tubules of rough-surfaced endoplasmic reticulum. The membranes induced by phenobarbital treatment persist in the cytoplasm of the hepatocyte for up to 15 days after the last of a series of 5 phenobarbital injections; the phase of regression of the induced enzymes lasts for only 5 days. Disappearance of the membranes is gradual and does not seem to be associated with increased autophagic activity in the cell. A second series of injections of phenobarbital to previously induced rats—exhibiting normal drug-hydroxylating activity but an excess of liver endoplasmic membranes—is associated with a stimulation of the rate of Pi32 incorporation into microsomal phospholipid in vivo, similar to that found during the original induction process. Administration of Actinomycin D following a single phenobarbital injection delays the regression of the enhanced drug-hydroxylating activity. Finally, the effects of Actinomycin D and puromycin on the stimulated membrane formation are discussed.

Dose-dependent effects of medroxyprogesterone acetate on the hepatic drug-metabolizing enzyme system in rats

1980 ◽  
Vol 29 (8) ◽  
pp. 1155-1159 ◽  
Author(s):  
Hannu Saarni ◽  
Jorma T. Ahokas ◽  
Niilo T. Karki ◽  
Olavi Pelkonen ◽  
Eero A. Sotaniem
Keyword(s):  
Medroxyprogesterone Acetate ◽  
Enzyme System ◽  
Hepatic Drug ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Dose Dependent

scholarly journals Effect of roseoflavin on microsomal drug-metabolizing enzyme system

FEBS Letters ◽  
1979 ◽  
Vol 98 (1) ◽  
pp. 49-52 ◽  
Author(s):  
István Horváth ◽  
Károly Tihanyi ◽  
Szabolcs Szeberényi ◽  
Shohei Otani
Keyword(s):  
Enzyme System ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme
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