Inhibitory effects of atropine and adrenergic antagonists on the changes in autonomic receptors and cyclic nucleotides of rat parotid and submandibular glands caused by sympathetic nerve stimulation

1988 ◽  
Vol 22 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Charlotte A. Schneyer ◽  
Michael Humphreys-Beher
Keyword(s):  
Nerve Stimulation ◽  
Cyclic Nucleotides ◽  
Sympathetic Nerve ◽  
Inhibitory Effects ◽  
Sympathetic Nerve Stimulation ◽  
Submandibular Glands ◽  
Adrenergic Antagonists ◽  
Autonomic Receptors ◽  
Rat Parotid

Effects on rat parotid amylase and Ca of alpha- and beta-adrenergic sympathetic stimulation.

1979 ◽  
Vol 236 (4) ◽  
pp. E371 ◽  
Author(s):  
D Jirakulsomchok ◽  
C A Schneyer
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Adrenergic Receptors ◽  
Amylase Activity ◽  
Salivary Flow ◽  
Beta Adrenergic Receptors ◽  
Sympathetic Nerve Stimulation ◽  
Beta Adrenergic ◽  
Rat Parotid ◽  
Stimulation Of

The roles of alpha- and beta-adrenergic receptors in the regulation of the secretion of amylase and calcium from rat parotid gland were studied by using direct electrical stimulation of the sympathetic innervation to the gland in the presence of selective adrenergic blocking agents. When phenoxybenzamine was administered intraperitoneally 25 min prior to nerve stimulation, the highest [Ca] (12-14 meq/liter) and amylase activity (1,000 mg/microliter) in the evoked saliva were observed. On the other hand, stimulation of the nerve in the presence of propranolol evoked a saliva that contained the lowest [Ca] (5-6 meq/liter) and amylase activity (170 mg/microliter). Furthermore, salivary flow (4.27 +/- 0.42 microliter/min X g) induced by sympathetic nerve stimulation in the presence of phenoxybenzamine was higher than that induced by sympathetic nerve stimulation in the presence of propranolol (2.55 +/- 0.39 microliter/min X g). Therefore, it was concluded that beta-adrenergic receptors play the major role in the regulation of salivary flow and the secretion of amylase and calcium, whereas alpha-adrenergic receptors play a minor role in the regulation of these parameters.

Interactive Effects of Verapamil and Sympathetic Nerve Stimulation on the Sinus and AV Nodes in the Canine Hearts.

1992 ◽  
Vol 33 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Katsusuke YANO ◽  
Masanobu HIRATA ◽  
Takao MITSUOKA ◽  
Yoriaki MATSUMOTO ◽  
Tetsuya HIRATA ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Interactive Effects ◽  
Sympathetic Nerve Stimulation
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