Parotid Salivary Gland Extramedullary Plasmacytoma with Local Lymph Node Metastasis in a Dog

ABSTRACT A 12 yr old spayed female mixed-breed dog presented for evaluation of a recurrent soft-tissue sarcoma. On physical examination, a firm mass was palpated ventral to the left ramus of the mandible. A fine-needle aspirate of the mass was suggestive of a round-cell neoplasm. A complete blood count, serum biochemical profile, and an abdominal ultrasound with liver and splenic aspirates were performed, and no clinically relevant abnormalities were identified. Advanced imaging of the skull identified an enlarged parotid salivary gland and an enlarged ipsilateral medial retropharyngeal lymph node. The medial retropharyngeal lymph node was sampled via fine-needle aspiration, and a round-cell population similar to what was present in the mass was identified. An incisional biopsy was performed under general anesthesia, which yielded a diagnosis of salivary gland extramedullary plasmacytoma, confirmed with immunohistochemistry (MUM-1). The parotid salivary gland and medial retropharyngeal lymph node were then surgically excised, and metastasis to the lymph node was confirmed by histopathology. The dog remained alive for 685 days after surgery until she was euthanized for hindlimb paresis of undetermined cause.

ULTRASOUND NAVIGATION IN SURGICAL TREATMENT OF PATIENTS WITH SALIVARY STONE DISEASE OF THE PAROTID SALIVARY GLAND. CLINICAL OBSERVATION

Objectives. To analyze the possibility of using the technique of intraoperative ultrasound navigation on surgical treatment of patients with salivary stone disease of the parotid salivary gland (PSG). Material and methods. A retrospective analysis of three medical records of an in-patient treated at the department of maxillofacial surgery and operative dentistry in Gomel Regional Clinical Hospital during the period from 2019 to 2021 for salivary stone disease of PSG was made. Results. The results of clinical observation of treatment of a patient with sialolithiasis of the parenchymal part of the PSG are presented. Taking into consideration the complexity of surgical removal of sialolites of this localization, the patient was initially treated conservatively which was of no effect. Salivary stones were removed using intraoperative ultrasound navigation which made it possible to successfully perform the surgical intervention, reduce surgical trauma, create conditions for structural and functional recovery of the PSG and reduce the possibility of the disease relapse by improving intraoperative visual control. Conclusions. The use of the technique of intraoperative ultrasound navigation in the surgical treatment of patients with salivary stone disease of the parotid salivary gland allows to remove the concrement, minimizing the trauma to the tissues of the operated area and the organ itself, maintaining adequate blood flow and architectonics in it, which enables the reduction in the number of postoperative complications, relapses of the disease and positively affects the quality of patients’ life.

The release of hydrolytic enzymes by the salivary glands and their content in the blood after unilateral nephrectomy

We studied the mechanisms of transformation of some salivary enzymes and established the real contribution of the salivary glands to the enzymatic homeostasis of the body in unilateral nephrectomy.The results were obtained that with unilateral nephrectomy, the content of amylase and pepsinogen in the blood increases, but its lipolytic activity remains unchanged, the volume of basal secretion of the salivary glands, the content and release of amylase by the parotid salivary gland increases. Unilateral nephrectomy stimulates the increment of pepsinogen by the gastric glands, and, accordingly, enhances its recreation from the blood, by the salivary glands. After unilateral nephrectomy, lipolytic activity and its secretion in saliva remain unchanged

The recurrence rate of pleomorphic adenoma in the long-term follow-up according to the clinic of maxillofacial surgery

In this study we sought to investigate the patients history database, underwent surgical treatment of removing pleomorphic adenoma amass form parotid gland (PG), also identifi replays of mass in the long-term follow-up period. Material and methods: 391 case histories of patients with benign tumours of the (PG) were analysed in detail. 200 (51,1%) patients had a morphological diagnosis of a pleomorphic adenoma (PA). During postoperative follow-up, 39 (n=39) patients were examined, During the ultrasound (sonography) examination were identify 7 patients with replays of neoplasm of parotid salivary gland (pleomorphic adenoma?), the average age of the patients at the time of the examination was 41.6±13.4 years (men — 42 years old, women — 48.8+11.8 years). The sex ratio of patients were 6 females and 1 male patient, the average time of relapse occurred in the long-term follow-up period was 8.3 years. The morphological study of prevues surgery of 7 patients with relapse of neoplasm of parotid salivary gland (pleomorphic adenoma ?), revealed a predominance of mixoid component in all patients, out of 5 patients with PA, the fibrous capsule had a complete structure, the capsule is partially or completely thinned in 1 patient, and in 1 patient is completely absent. Conclusion: By retrospective analysis of the data of patients who underwent to surgery of parotid gland surdested that the likelihood of tumor recurrence increases with the predominance of the myxold component in the structure of pleomorphic adenoma, especially in those where it is limited to the use of the method of ectracapsular enucleation, performed even in an extended version within the surface part of the parotid gland. In addition, the risk of recurrence increases with morphological signs of complete or partial absence of the fibrous capsule of the PA.

Aggressive giant dermatofibrosarcoma protuberance occurring in the parotid gland: Clinical case

Relevance: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous malignancy that arises from the dermis and invades deeper tissue. The cellular origin of DFSP is not clear. Evidence supports a fibroblastic, histiocytic, or neuroectodermal cellular origin. The article shares a clinical case of the treatment of aggressive dermatofibrosarcoma of the parotid salivary gland and describes the sequence of treatment and the treatment outcome. Results: A 38 years-old woman with a slow-growing large right parotid mass underwent a total parotidectomy with auriculectomy and reconstruction using ALT flap. The surgery in the scope of a wide resection was followed by 4 cycles of chemotherapy and postoperative radiotherapy up to 40 Gy. The tumor recurrence after 10 months was treated by the second surgery followed by chemoradiotherapy. No new recurrence was observed in the following two years. Conclusion: In the observed case, the giant tumor in the parotid salivary gland recurred after the initial surgery and adjuvant treatment. A tumor in the parotid region can recur despite aggressive initial treatment with wide resection and chemoradiotherapy.