Fine-needle aspiration cytology of giant cell tumor of soft tissue (soft tissue giant cell tumor of low malignant potential)

2003 ◽  
Vol 7 (6) ◽  
pp. 365-369 ◽  
Author(s):  
Matthew Beal ◽  
Joel Mayerson ◽  
Paul E Wakely
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Needle Aspiration ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Low Malignant Potential ◽  
Needle Aspiration Cytology

Fine Needle Aspiration Cytology of Diffuse-Type Tenosynovial Giant Cell Tumors

2017 ◽  
Vol 61 (2) ◽  
pp. 160-164 ◽  
Author(s):  
Zimin Zhao ◽  
Cherie Paquette ◽  
Akeesha A. Shah ◽  
Kristen A. Atkins ◽  
Henry F. Frierson
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Cell Tumor ◽  
Diffuse Type ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Tenosynovial giant cell tumor (TSGCT), also known as giant cell tumor of tendon sheath or pigmented villonodular synovitis, is the most common benign tumor of the tendon and synovium. The intra-articular diffuse type can present as a large infiltrative mass involving adjacent soft tissue and sometimes causes secondary destruction of bone, which leads to radiographic and clinical concern for malignancy. The tumor may also be purely extra-articular. Case: Here, we report the fine needle aspiration cytology findings of 2 cases of diffuse-type TSGCT with large mononuclear cells with eccentric nuclei, finely granular cytoplasm, and a peripheral well-defined cytoplasmic rim of hemosiderin (“ladybird cells”). Conclusion: Although the presence of ladybird cells has been described in tissue sections of TSGCT, their identification in cytological specimens has not been reported to our knowledge. When observed, their presence may aid in differentiating TSGCT from other lesions with multinucleated osteoclast-type giant cells occurring at or near joints.

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