Inflammation-induced hyperalgesia: Effects of timing, dosage, and negative affect on somatic pain sensitivity in human experimental endotoxemia

2014 ◽  
Vol 41 ◽  
pp. 46-54 ◽  
Author(s):  
Alexander Wegner ◽  
Sigrid Elsenbruch ◽  
Janina Maluck ◽  
Jan-Sebastian Grigoleit ◽  
Harald Engler ◽  
...  
Keyword(s):  
Negative Affect ◽  
Pain Sensitivity ◽  
Experimental Endotoxemia ◽  
Somatic Pain ◽  
Somatic Pain Sensitivity

Experimental endotoxemia as a model to study somatic pain sensitivity in humans

2013 ◽  
Vol 29 ◽  
pp. S19
Author(s):  
Alexander Wegner ◽  
Janina Malluck ◽  
Manfred Schedlowski ◽  
Sigrid Elsenbruch ◽  
Sven Benson
Keyword(s):  
Pain Sensitivity ◽  
Experimental Endotoxemia ◽  
Somatic Pain ◽  
Somatic Pain Sensitivity

scholarly journals Impact of hypertension on somatic pain sensitivity in chronic headache

2013 ◽  
Vol 1 (Suppl 1) ◽  
pp. P160
Author(s):  
ET Tafuri ◽  
S Di Fabio ◽  
E Cozza ◽  
GP Affaitati ◽  
A Fabrizio ◽  
...  
Keyword(s):  
Chronic Headache ◽  
Pain Sensitivity ◽  
Somatic Pain ◽  
Somatic Pain Sensitivity

Physiological and Pharmacological Effects of Glucocorticoids on the Gastrointestinal Tract

2020 ◽  
Vol 26 (25) ◽  
pp. 2962-2970 ◽  
Author(s):  
Ludmila Filaretova ◽  
Tatiana Podvigina ◽  
Natalia Yarushkina
Keyword(s):  
Gastrointestinal Tract ◽  
Gastric Mucosa ◽  
Pain Sensitivity ◽  
Experimental Studies ◽  
Pharmacological Effects ◽  
Somatic Pain ◽  
Gastrointestinal Injury ◽  
Mucosal Integrity ◽  
Somatic Pain Sensitivity

The review considers the data on the physiological and pharmacological effects of glucocorticoids on the gastric mucosa and focuses on the gastroprotective role of stress-produced glucocorticoids as well as on the transformation of physiological gastroprotective effects of glucocorticoids to pathological proulcerogenic consequences. The results of experimental studies on the re-evaluation of the traditional notion that stress-produced glucocorticoids are ulcerogenic led us to the opposite conclusion suggested that these hormones play an important role in the maintenance of the gastric mucosal integrity. Exogenous glucocorticoids may exert both gastroprotective and proulcerogenic effects. Initially, gastroprotective effect of dexamethasone but not corticosterone, cortisol or prednisolone can be transformed into proulcerogenic one. The most significant factor for the transformation is the prolongation of its action rather the dose. Gastrointestinal injury can be accompanied by changes in somatic pain sensitivity and glucocorticoids contribute to these changes playing a physiological and pathological role.

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