scholarly journals Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog

2021 ◽  
Vol 141 ◽  
pp. 111861
Author(s):  
Magali Chartier ◽  
Michael Desgagné ◽  
Marc Sousbie ◽  
Charles Rumsby ◽  
Lucie Chevillard ◽  
...  
Keyword(s):  
Receptor Type ◽  
Neurotensin Receptor ◽  
Pharmacokinetic Profiles

scholarly journals Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

2015 ◽  
Vol 25 (2) ◽  
pp. 292-296 ◽  
Author(s):  
James B. Thomas ◽  
Angela M. Giddings ◽  
Srinivas Olepu ◽  
Robert W. Wiethe ◽  
Danni L. Harris ◽  
...  
Keyword(s):  
Receptor Type ◽  
Neurotensin Receptor

scholarly journals Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

2014 ◽  
Vol 57 (12) ◽  
pp. 5318-5332 ◽  
Author(s):  
James B. Thomas ◽  
Angela M. Giddings ◽  
Robert W. Wiethe ◽  
Srinivas Olepu ◽  
Keith R. Warner ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Receptor Type ◽  
Neurotensin Receptor ◽  
Cyclohexane Carboxylic Acid

scholarly journals The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

2015 ◽  
Vol 25 (10) ◽  
pp. 2060-2064 ◽  
Author(s):  
James B. Thomas ◽  
Angela M. Giddings ◽  
Srinivas Olepu ◽  
Robert W. Wiethe ◽  
Keith R. Warner ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Receptor Type ◽  
Receptor Ligands ◽  
Neurotensin Receptor

scholarly journals Identification of N-[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

2014 ◽  
Vol 57 (17) ◽  
pp. 7472-7477 ◽  
Author(s):  
James B. Thomas ◽  
Angela M. Giddings ◽  
Robert W. Wiethe ◽  
Srinivas Olepu ◽  
Keith R. Warner ◽  
...  
Keyword(s):  
Receptor Type ◽  
Neurotensin Receptor

scholarly journals Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukemia cells from apoptosis

Oncogene ◽  
2017 ◽  
Vol 37 (6) ◽  
pp. 756-767 ◽  
Author(s):  
A Abbaci ◽  
H Talbot ◽  
S Saada ◽  
N Gachard ◽  
J Abraham ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Receptor Type ◽  
Leukemia Cells ◽  
Neurotensin Receptor ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic

2021 ◽  
Vol 64 (4) ◽  
pp. 2110-2124
Author(s):  
Magali Chartier ◽  
Michael Desgagné ◽  
Marc Sousbie ◽  
Jérôme Côté ◽  
Jean-Michel Longpré ◽  
...  
Keyword(s):  
Structural Optimization ◽  
Opioid Analgesic ◽  
Receptor Type ◽  
Neurotensin Receptor
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