Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors

Weiping Zhuang; Xueqing Zhao; Gang Zhao; Lihe Guo; Yunyang Lian; Jingming Zhou; Dongsheng Fang

doi:10.1016/j.bmc.2009.08.010

Synthesis and biological evaluation of 4-fluoroproline and 4-fluoropyrrolidine-2-acetic acid derivatives as new GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.08.010 ◽

2009 ◽

Vol 17 (18) ◽

pp. 6540-6546 ◽

Cited By ~ 9

Author(s):

Weiping Zhuang ◽

Xueqing Zhao ◽

Gang Zhao ◽

Lihe Guo ◽

Yunyang Lian ◽

...

Keyword(s):

Acetic Acid ◽

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2004.11.004 ◽

2005 ◽

Vol 40 (3) ◽

pp. 231-247 ◽

Cited By ~ 18

Author(s):

Xueqing Zhao ◽

Cornelia E. Hoesl ◽

Georg C. Hoefner ◽

Klaus T. Wanner

Keyword(s):

Acetic Acid ◽

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.01.024 ◽

2019 ◽

Vol 27 (5) ◽

pp. 822-831 ◽

Cited By ~ 1

Author(s):

Krisztián Tóth ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Nipecotic Acid ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.05.049 ◽

2018 ◽

Vol 26 (12) ◽

pp. 3668-3687 ◽

Cited By ~ 5

Author(s):

Krisztián Tóth ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Nipecotic Acid ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of 4-hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.11.015 ◽

2013 ◽

Vol 21 (2) ◽

pp. 470-484 ◽

Cited By ~ 4

Author(s):

Xueqing Zhao ◽

Jörg Pabel ◽

Georg C. Höfner ◽

Klaus T. Wanner

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors ◽

Ylacetic Acid

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Design, Synthesis, and Biological Evaluation of the N-Diarylalkenyl-piperidinecarboxylic Acid Derivatives as GABA Uptake Inhibitors (I).

ChemInform ◽

10.1002/chin.200614141 ◽

2006 ◽

Vol 37 (14) ◽

Author(s):

Jianbin Zheng ◽

Ren Wen ◽

Xiaomin Luo ◽

Guoqiang Lin ◽

Jiange Zhang ◽

...

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Design Synthesis ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Design, synthesis, and biological evaluation of the N-diarylalkenyl-piperidinecarboxylic acid derivatives as GABA uptake inhibitors (I)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.09.004 ◽

2006 ◽

Vol 16 (1) ◽

pp. 225-227 ◽

Cited By ~ 14

Author(s):

Jianbin Zheng ◽

Ren Wen ◽

Xiaomin Luo ◽

Guoqiang Lin ◽

Jiange Zhang ◽

...

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Design Synthesis ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.11.002 ◽

2018 ◽

Vol 26 (22) ◽

pp. 5944-5961 ◽

Cited By ~ 4

Author(s):

Krisztián Tóth ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Nipecotic Acid ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.04.010 ◽

2007 ◽

Vol 17 (13) ◽

pp. 3769-3773 ◽

Cited By ~ 10

Author(s):

Jiange Zhang ◽

Pei Zhang ◽

Xianbo Liu ◽

Kai Fang ◽

Guoqiang Lin

Keyword(s):

Carboxylic Acid ◽

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of a series of N -alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.09.012 ◽

2016 ◽

Vol 124 ◽

pp. 852-880 ◽

Cited By ~ 8

Author(s):

Silke Kerscher-Hack ◽

Thejavathi Renukappa-Gutke ◽

Georg Höfner ◽

Klaus T. Wanner

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Alkanoic Acids ◽

Synthesis And Biological Evaluation ◽

Gaba Uptake Inhibitors

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Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2010.11.001 ◽

2011 ◽

Vol 46 (1) ◽

pp. 183-190 ◽

Cited By ~ 14

Author(s):

Katarzyna Kulig ◽

Krzysztof Więckowski ◽

Anna Więckowska ◽

Justyna Gajda ◽

Bartłomiej Pochwat ◽

...

Keyword(s):

Biological Evaluation ◽

Gaba Uptake ◽

Uptake Inhibitors ◽

Synthesis And Biological Evaluation ◽

Derivatives Of ◽

Gaba Uptake Inhibitors

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