Discovery and characterization of a novel series of N -phenylsulfonyl-1 H -pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu 4 )

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.040 ◽

2017 ◽

Vol 115 ◽

pp. 115-127 ◽

Cited By ~ 5

Author(s):

L. Lundström ◽

C. Bissantz ◽

J. Beck ◽

M. Dellenbach ◽

T.J. Woltering ◽

...

Keyword(s):

Molecular Characterization ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Neuropharmacology ◽

10.1016/j.neuropharm.2016.08.032 ◽

2016 ◽

Vol 111 ◽

pp. 253-265 ◽

Cited By ~ 3

Author(s):

L. Lundström ◽

C. Bissantz ◽

J. Beck ◽

M. Dellenbach ◽

T.J. Woltering ◽

...

Keyword(s):

Molecular Characterization ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Discovery, Structure–Activity Relationship, and Biological Characterization of a Novel Series of 6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-benzo[d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b00994 ◽

2018 ◽

Vol 62 (1) ◽

pp. 342-358 ◽

Cited By ~ 7

Author(s):

Sean R. Bollinger ◽

Darren W. Engers ◽

Joseph D. Panarese ◽

Mary West ◽

Julie L. Engers ◽

...

Keyword(s):

Glutamate Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulators ◽

Biological Characterization ◽

Metabotropic Glutamate ◽

Structure Activity ◽

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

ChemMedChem ◽

10.1002/cmdc.201402190 ◽

2014 ◽

Vol 9 (12) ◽

pp. 2685-2698 ◽

Cited By ~ 1

Author(s):

Xavier Rovira ◽

Youssef Harrak ◽

Ana Trapero ◽

Patricia González-Bulnes ◽

Fanny Malhaire ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Active Conformation ◽

Metabotropic Glutamate ◽

Cyclohexane Carboxylate ◽

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.10.050 ◽

2015 ◽

Vol 25 (24) ◽

pp. 5792-5796 ◽

Cited By ~ 5

Author(s):

John M. Ellard ◽

Andrew Madin ◽

Oliver Philps ◽

Mark Hopkin ◽

Scott Henderson ◽

...

Keyword(s):

Glutamate Receptor ◽

Preclinical Model ◽

Allosteric Modulators ◽

Improve Performance ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse?

Biological Psychiatry ◽

10.1016/j.biopsych.2015.07.008 ◽

2015 ◽

Vol 78 (7) ◽

pp. 436-438 ◽

Cited By ~ 1

Author(s):

Kari A. Johnson ◽

David M. Lovinger

Keyword(s):

Drug Abuse ◽

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

Expert Opinion on Therapeutic Patents ◽

10.1517/13543770903045009 ◽

2009 ◽

Vol 19 (9) ◽

pp. 1259-1275 ◽

Cited By ~ 36

Author(s):

Mark E Fraley

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

N-Aryl Piperazine Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators Possess Efficacy in Preclinical Models of NMDA Hypofunction and Cognitive Enhancement

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.206623 ◽

2013 ◽

Vol 347 (2) ◽

pp. 438-457 ◽

Cited By ~ 34

Author(s):

K.J. Gregory ◽

E.J. Herman ◽

A.J. Ramsey ◽

A.S. Hammond ◽

N.E. Byun ◽

...

Keyword(s):

Glutamate Receptor ◽

Cognitive Enhancement ◽

Allosteric Modulators ◽

Preclinical Models ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators

ACS Medicinal Chemistry Letters ◽

10.1021/acsmedchemlett.6b00292 ◽

2016 ◽

Vol 7 (12) ◽

pp. 1082-1086 ◽

Cited By ~ 12

Author(s):

Matthew D. Hill ◽

Haiquan Fang ◽

Jeffrey M. Brown ◽

Thaddeus Molski ◽

Amy Easton ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.12.048 ◽

2011 ◽

Vol 21 (3) ◽

pp. 971-976 ◽

Cited By ~ 15

Author(s):

Andrés A. Trabanco ◽

Guillaume Duvey ◽

José María Cid ◽

Gregor J. Macdonald ◽

Philippe Cluzeau ◽

...

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽