Virus-like particles against infectious disease and cancer: guidance for the nano-architect

Current Opinion in Biotechnology ◽

10.1016/j.copbio.2021.09.012 ◽

2022 ◽

Vol 73 ◽

pp. 346-354

Author(s):

Rory A Hills ◽

Mark Howarth

Keyword(s):

Infectious Disease ◽

Virus Like Particles

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Virus-Like Particles as vaccine antigens and adjuvants: application to chronic disease, cancer immunotherapy and infectious disease preventive strategies

Procedia in Vaccinology ◽

10.1016/j.provac.2010.07.004 ◽

2010 ◽

Vol 2 (2) ◽

pp. 128-133 ◽

Cited By ~ 5

Author(s):

G. Guillén ◽

J.C. Aguilar ◽

S. Dueñas ◽

L. Hermida ◽

M.G. Guzmán ◽

...

Keyword(s):

Infectious Disease ◽

Chronic Disease ◽

Cancer Immunotherapy ◽

Preventive Strategies ◽

Virus Like Particles ◽

Vaccine Antigens

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Tissue section lifting for electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081292 ◽

1978 ◽

Vol 36 (2) ◽

pp. 86-87

Author(s):

Adrian F. van Dellen

Keyword(s):

Infectious Disease ◽

Electron Microscopy ◽

Tissue Culture ◽

Organ System ◽

Surrounding Tissue ◽

Paraffin Sections ◽

Surface Areas ◽

Specific Determination ◽

High Degree ◽

Accuracy And Repeatability

The morphologic pathologist may require information on the ultrastructure of a non-specific lesion seen under the light microscope before he can make a specific determination. Such lesions, when caused by infectious disease agents, may be sparsely distributed in any organ system. Tissue culture systems, too, may only have widely dispersed foci suitable for ultrastructural study. In these situations, when only a few, small foci in large tissue areas are useful for electron microscopy, it is advantageous to employ a methodology which rapidly selects a single tissue focus that is expected to yield beneficial ultrastructural data from amongst the surrounding tissue. This is in essence what "LIFTING" accomplishes. We have developed LIFTING to a high degree of accuracy and repeatability utilizing the Microlift (Fig 1), and have successfully applied it to tissue culture monolayers, histologic paraffin sections, and tissue blocks with large surface areas that had been initially fixed for either light or electron microscopy.

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