Ruthenium (III) Catalysed and Uncatalysed Oxidation of Torsemide by Hexacyanoferrate (III) in Aqueous Alkaline Medium: A Kinetic Comparative Approach

2021 ◽  
pp. 100104
Author(s):  
Ravindra K.S ◽  
Vidyavati A. Shastry ◽  
Mohan Kumar ◽  
H. Nagarajaiah ◽  
Ramyashree H
Keyword(s):  
Alkaline Medium ◽  
Comparative Approach ◽  
Aqueous Alkaline Medium

Linear Synthesis of {4-[(2-Alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones as Possible Therapeutic Agents

2019 ◽  
Vol 41 (4) ◽  
pp. 685-685
Author(s):  
Muhammad Athar Abbasi Muhammad Athar Abbasi ◽  
Wajiha Khan Wajiha Khan ◽  
Aziz ur Rehman Aziz ur Rehman ◽  
Sabahat Zahra Siddiqui Sabahat Zahra Siddiqui ◽  
Ghulam Hussain Ghulam Hussain ◽  
...  
Keyword(s):  
Alkaline Medium ◽  
Inhibitory Activity ◽  
Substitution Reaction ◽  
Parent Compound ◽  
Ph Control ◽  
Therapeutic Agents ◽  
Lithium Hydride ◽  
Aqueous Alkaline Medium

In the present work, a series of {4-[(2-alkyloxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones was synthesized through a linear bi-step approach. The synthesis was initiated by the coupling of 2-furyl(1-piperazinyl)methanone (1) with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) under dynamic pH control in aqueous alkaline medium to form parent compound, {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanone (3). Then, the O-substitution reaction on nucleophile 3 was carried out by treating it with different alkyl/aralkyl halides (4a-l) in the presence of lithium hydride (LiH) and N,N-dimethylformamide (DMF) to obtained the designed {4-[(2-alkoxy/aralkyloxy-3,5-dichlorophenyl)sulfonyl]-1-piperazinyl}(2-furyl)methanones (5a-l). These synthesized compounds were screened against α-glucosidase enzyme and some of them exhibited considerable inhibitory activity. Additionally, compounds were also evaluated for hemolytic and cytotoxic profile.

Studies on the ketone-catalyzed decomposition of caroate in aqueous alkaline medium

2005 ◽  
Vol 37 (8) ◽  
pp. 483-488 ◽  
Author(s):  
S. Selvararani ◽  
B. Medona ◽  
M. S. Ramachandran
Keyword(s):  
Alkaline Medium ◽  
Aqueous Alkaline Medium
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