Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

Christopher B. Roth; Michael A. Hanson; Raymond C. Stevens

doi:10.1016/j.jmb.2007.12.028

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

Journal of Molecular Biology ◽

10.1016/j.jmb.2007.12.028 ◽

2008 ◽

Vol 376 (5) ◽

pp. 1305-1319 ◽

Cited By ~ 92

Author(s):

Christopher B. Roth ◽

Michael A. Hanson ◽

Raymond C. Stevens

Keyword(s):

Adrenergic Receptor ◽

Critical Residue ◽

Β2 Adrenergic Receptor ◽

Gpcr Structure

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Faculty Opinions recommendation of Agonist-directed desensitization of the β2-adrenergic receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11025956.11972054 ◽

2011 ◽

Author(s):

Celeste Finnerty

Keyword(s):

Adrenergic Receptor ◽

Β2 Adrenergic Receptor

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Faculty Opinions recommendation of Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12092957.13877054 ◽

2011 ◽

Author(s):

Marc Caron ◽

Arun Shukla

Keyword(s):

Crystal Structure ◽

Protein Complex ◽

Adrenergic Receptor ◽

Β2 Adrenergic Receptor ◽

Gs Protein

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Faculty Opinions recommendation of Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12092957.13584054 ◽

2011 ◽

Author(s):

Christopher Janetopoulos

Keyword(s):

Crystal Structure ◽

Protein Complex ◽

Adrenergic Receptor ◽

Β2 Adrenergic Receptor ◽

Gs Protein

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Faculty Opinions recommendation of Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12092957.13491054 ◽

2011 ◽

Author(s):

Thomas Meier

Keyword(s):

Crystal Structure ◽

Protein Complex ◽

Adrenergic Receptor ◽

Β2 Adrenergic Receptor ◽

Gs Protein

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Faculty Opinions recommendation of Multiple ligand-specific conformations of the β2-adrenergic receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.12979957.14287055 ◽

2011 ◽

Author(s):

Robert Copeland

Keyword(s):

Adrenergic Receptor ◽

Β2 Adrenergic Receptor ◽

Multiple Ligand

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Faculty Opinions recommendation of Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13497961.14871099 ◽

2012 ◽

Author(s):

Gebhard Schertler ◽

Dmitry Veprintsev

Keyword(s):

Signaling Pathways ◽

Adrenergic Receptor ◽

19F Nmr ◽

Biased Signaling ◽

Β2 Adrenergic Receptor

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Faculty Opinions recommendation of Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725503679.793524084 ◽

2016 ◽

Author(s):

Ayyalusamy Ramamoorthy

Keyword(s):

Dynamic Process ◽

Adrenergic Receptor ◽

Receptor Signaling ◽

Β2 Adrenergic Receptor ◽

Structural Insights

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Faculty Opinions recommendation of Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726306316.793521688 ◽

2016 ◽

Author(s):

Gerald Zamponi

Keyword(s):

Adrenergic Receptor ◽

Β2 Adrenergic Receptor

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Faculty Opinions recommendation of β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727146583.793527403 ◽

2017 ◽

Author(s):

Alan Smrcka

Keyword(s):

Adrenergic Receptor ◽

Receptor Signaling ◽

Β2 Adrenergic Receptor

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Faculty Opinions recommendation of Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727537208.793533379 ◽

2017 ◽

Author(s):

Dimitrios Morikis

Keyword(s):

Functional Analysis ◽

Adrenergic Receptor ◽

Receptor Complex ◽

Β2 Adrenergic Receptor

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