scholarly journals A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies

2012 ◽  
Vol 66 ◽  
pp. 371-375 ◽  
Author(s):  
Hongxia Lin ◽  
Murugesan K. Gounder ◽  
Joseph R. Bertino ◽  
Ah-Ng Tony Kong ◽  
Robert S. DiPaola ◽  
...  
Keyword(s):  
Human Plasma ◽  
Clinical Pharmacokinetic ◽  
Pharmacokinetic Studies ◽  
Hplc Assay

A validated ultra-HPLC–MS/MS method for determination of honokiol in human plasma and its application to a clinical pharmacokinetic study

Bioanalysis ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1085-1098 ◽  
Author(s):  
Quankun Zhuang ◽  
Ruili Pan ◽  
Xuemei Liu ◽  
Wen Xu ◽  
Hanping Wang ◽  
...  
Keyword(s):  
Human Plasma ◽  
Clinical Pharmacokinetic ◽  
Pharmacokinetic Study

Direct-injection HPLC assay for the determination of a new carbapenem antibiotic in human plasma and urine

2002 ◽  
Vol 27 (5) ◽  
pp. 755-770 ◽  
Author(s):  
Jin Zhang ◽  
Donald G Musson ◽  
Kimberly L Birk ◽  
Ann M Cairns ◽  
Alison L Fisher ◽  
...  
Keyword(s):  
Human Plasma ◽  
Direct Injection ◽  
Hplc Assay ◽  
Human Plasma And Urine ◽  
Carbapenem Antibiotic

AN EFFICIENT HPLC-UV METHOD FOR THE QUANTITATIVE DETERMINATION OF CEFADROXIL IN HUMAN PLASMA AND ITS APPLICATION IN PHARMACOKINETIC STUDIES

2012 ◽  
Vol 35 (13) ◽  
pp. 1871-1881 ◽  
Author(s):  
Eunice Kazue Kano ◽  
Cristina Helena dos Reis Serra ◽  
Eunice Emiko Mori Koono ◽  
Kazuo Fukuda ◽  
Valentina Porta
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Pharmacokinetic Studies

Simultaneous determination of novel ketolide antibiotic nafithromycin and its major metabolite in human plasma using liquid chromatography tandem mass spectrometry

Bioanalysis ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 1767-1776
Author(s):  
Kiran R Patil ◽  
Ravindra D Yeole ◽  
Marcel de Zwart ◽  
Peter Pruim
Keyword(s):  
Phase I ◽  
Human Plasma ◽  
Internal Standard ◽  
Pharmacokinetic Studies ◽  
Simultaneous Quantification ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Us Fda ◽  
Standard Protein

Aim: A sensitive method to quantify nafithromycin and its N-desmethyl metabolite in human plasma was necessary for Phase I pharmacokinetic studies. Methodology: A precise and accurate LC–MS/MS bioanalytical method has been developed and validated for the simultaneous quantification of nafithromycin (NFT, WCK 4873) and N-desmethyl metabolite (M1, WCK 4978) in human plasma. Clarithromycin was used as an internal standard. Protein precipitation technique was used as sample preparation approach. The calibration curve was linear (r ≥ 0.99) over the concentration range of 10–5000 ng/ml for NFT and M1. Method was validated as per US FDA guideline. Conclusion: The proposed method was successfully applied for determination of plasma levels of the NFT and M1 during Phase I clinical studies.

Determination of total or free cefazolin and metronidazole in human plasma or interstitial fluid by HPLC-UV for pharmacokinetic studies in man

2019 ◽  
Vol 1118-1119 ◽  
pp. 51-54 ◽  
Author(s):  
Christoph Dorn ◽  
Alexander Kratzer ◽  
Selina Schießer ◽  
Frieder Kees ◽  
Hermann Wrigge ◽  
...  
Keyword(s):  
Human Plasma ◽  
Interstitial Fluid ◽  
Pharmacokinetic Studies

scholarly journals Validated LC–MS/MS Assay for the Quantitative Determination of Fimasartan in Human Plasma: Application to Pharmacokinetic Studies

2015 ◽  
Vol 53 (8) ◽  
pp. 1250-1256 ◽  
Author(s):  
Seo Hyun Yoon ◽  
Seul Oh ◽  
Hwa Suk Kim ◽  
SoJeong Yi ◽  
Kyung-Sang Yu ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Pharmacokinetic Studies
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