Late saphenous vein graft occlusion in patients with coronary bypass: possible role of aspirin resistance

2005 ◽  
Vol 115 (1-2) ◽  
pp. 25-29 ◽  
Author(s):  
Mehmet Birhan Yilmaz ◽  
Yucel Balbay ◽  
Vedat Caldir ◽  
Selime Ayaz ◽  
Yesim Guray ◽  
...  
2021 ◽  
Author(s):  
Dudy Arman hanafy ◽  
Budhi Setianto Setianto ◽  
Jusuf Rachmat ◽  
Soesanto ◽  
Arman Adel Abdullah ◽  
...  

Abstract Objectives: This study was carried out to determine the role of pre-operative and transient aspirin resistance in the formation of early saphenous vein graft (SVG) thrombosis six weeks after coronary artery bypass graft (CABG) surgery and to analyze the other factors, such as mechanical and inflammation factors, that are also suspected of contributing to the formation of early thrombosis.Methods: Pre- and post-operative blood samples were taken from 99 subjects, whom 74 patients were undergoing elective on-pump CABG and receiving aspirin as monotherapy, for evaluation of inflammation parameters and the state of aspirin resistance using a Platelet Function Analyzer-200 (PFA-200). Transit time flow measurements (TTFM) were performed intra-operatively to determine mechanical factors. Multi-sliced computed tomography (MSCT) was done six weeks after surgery to determine the patency of the vein grafts.Result: In the 222 vein conduits, aspirin resistance was related to early vein graft failure due to thrombosis (p < 0.001; relative risk (RR) = 3.69). The massive increase of interleukin 6 (IL-6) levels after surgery were related to the existence of post-operative transient aspirin resistance (p < 0.001). Transient aspirin resistance (IL-6 > 122.5) was associated with early graft failure (p = 0.029; RR = 8.6) compared to the aspirin-sensitive group (IL-6 > 122.5).Conclusion: Aspirin resistance plays a primary role in early vein graft thrombosis. Transient aspirin resistance accompanied by an increase of inflammation factor (IL-6) significantly increases the risk of early vein graft thrombosis after CABG.


1991 ◽  
Vol 17 (2) ◽  
pp. A120
Author(s):  
G.V.R.K. Sharma ◽  
Gulshan Sethi ◽  
Tom Moritz ◽  
Diane Lapsley ◽  
Shukri Khuri ◽  
...  

2010 ◽  
Vol 21 (2) ◽  
pp. 61-64 ◽  
Author(s):  
Rainer Hoffmann ◽  
Giadino Nitendo ◽  
Verena Deserno ◽  
Umar Adamu ◽  
Mohammed Almalla ◽  
...  

Vascular ◽  
2017 ◽  
Vol 26 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Jeremy Kaisar ◽  
Aaron Chen ◽  
Mathew Cheung ◽  
Elias Kfoury ◽  
Carlos F Bechara ◽  
...  

Introduction Heparin-bonded expanded polytetrafluoroethylene grafts (Propaten, WL Gore, Flagstaff, AZ, USA) have been shown to have superior patency compared to standard prosthetic grafts in leg bypass. This study analyzed the outcomes of Propaten grafts with distal anastomotic patch versus autogenous saphenous vein grafts in tibial artery bypass. Methods A retrospective analysis of prospective collected data was performed during a recent 15-year period. Sixty-two Propaten bypass grafts with distal anastomotic patch (Propaten group) were compared with 46 saphenous vein graft (vein group). Pertinent clinical variables including graft patency and limb salvage were analyzed. Results Both groups had similar clinical risk factors, bypass indications, and target vessel for tibial artery anastomoses. Decreased trends of operative time (196 ± 34 min vs. 287 ± 65 min, p = 0.07) and length of hospital stay (5.2 ± 2.3 days vs. 7.5 ± 3.6, p = 0.08) were noted in the Propaten group compared to the vein group. Similar primary patency rates were noted at four years between the Propaten and vein groups (85%, 71%, 64%, and 57%, vs. 87%, 78%, 67%, and 61% respectively; p = 0.97). Both groups had comparable secondary patency rates yearly in four years (the Propaten group: 84%, 76%, 74%, and 67%, respectively; the vein group: 88%, 79%, 76%, and 72%, respectively; p = 0.94). The limb salvage rates were equivalent between the Propaten and vein group at four years (84% vs. 92%, p = 0.89). Multivariate analysis showed active tobacco usage and poor run-off score as predictors for graft occlusion. Conclusions Propaten grafts with distal anastomotic patch have similar clinical outcomes compared to the saphenous vein graft in tibial artery bypass. Our data support the use of Propaten graft with distal anastomotic patch as a viable conduit of choice in patients undergoing tibial artery bypass.


2010 ◽  
Vol 30 (2) ◽  
pp. 603-609
Author(s):  
Göksel ÇAĞIRCI ◽  
Özcan ÖZDEMİR ◽  
Sevinç YILMAZ ◽  
Selime AYAZ ◽  
Dursun ARAS ◽  
...  

2010 ◽  
Vol 106 (12) ◽  
pp. 1721-1727 ◽  
Author(s):  
Rasha Al-Lamee ◽  
Alfonso Ielasi ◽  
Azeem Latib ◽  
Cosmo Godino ◽  
Massimo Ferraro ◽  
...  

2017 ◽  
Vol 26 ◽  
pp. S382
Author(s):  
Alistair Royse ◽  
Zulfayandi Pawanis ◽  
Colin Royse ◽  
Sandra Clarke ◽  
Jared Ou-Young ◽  
...  

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