scholarly journals Effects of interferon on immediate-early mRNA and protein levels in sensory neuronal cells infected with herpes simplex virus type 1 or pseudorabies virus

2011 ◽  
Vol 152 (3-4) ◽  
pp. 401-406 ◽  
Author(s):  
Nina Van Opdenbosch ◽  
Nick De Regge ◽  
Mario Van Poucke ◽  
Luc Peelman ◽  
Herman W. Favoreel
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Pseudorabies Virus ◽  
Neuronal Cells ◽  
Immediate Early ◽  
Protein Levels ◽  
Simplex Virus

scholarly journals Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

1988 ◽  
Vol 8 (1) ◽  
pp. 457-460 ◽  
Author(s):  
T D Palella ◽  
L J Silverman ◽  
C T Schroll ◽  
F L Homa ◽  
M Levine ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Neuronal Cells ◽  
Neurological Dysfunction ◽  
Hprt Gene ◽  
Hypoxanthine Guanine Phosphoribosyltransferase ◽  
Simplex Virus

The virtually complete deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a devastating neurological disease, Lesch-Nyhan syndrome. Transfer of the HPRT gene into fibroblasts and lymphoblasts in vitro and into hematopoietic cells in vivo has been accomplished by other groups with retroviral-derived vectors. It appears to be necessary, however, to transfer the HPRT gene into neuronal cells to correct the neurological dysfunction of this disorder. The neurotropic virus herpes simplex virus type 1 has features that make it suitable for use as a vector to transfer the HPRT gene into neuronal tissue. This report describes the isolation of an HPRT-deficient rat neuroma cell line, designated B103-4C, and the construction of a recombinant herpes simplex virus type 1 that contained human HPRT cDNA. These recombinant viruses were used to infect B103-4C cells. Infected cells expressed HPRT activity which was human in origin.

scholarly journals Stable induction of a 51K cellular protein in neuronal cells surviving herpes simplex virus type 1 infection

Virology ◽  
1985 ◽  
Vol 142 (2) ◽  
pp. 398-405
Author(s):  
Alan L. Goldin ◽  
Rozanne M. Sandri-Goldin ◽  
Joseph C. Glorioso ◽  
Myron Levine
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Neuronal Cells ◽  
Cellular Protein ◽  
Simplex Virus
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