Nitric oxide increases hepatic arterial blood flow in rats with carbon tetrachloride–induced acute hepatic injury

1999 ◽  
Vol 117 (1) ◽  
pp. 173-180 ◽  
Author(s):  
Noriko Tanaka ◽  
Katsuaki Tanaka ◽  
Yoji Nagashima ◽  
Masaaki Kondo ◽  
Hisahiko Sekihara
1997 ◽  
Vol 161 (3) ◽  
pp. 303-309 ◽  
Author(s):  
F. GRUND ◽  
H. T. SOMMERSCHILD ◽  
A. WINECOFF ◽  
M. R. UJHELYI ◽  
T. TØNNESSEN ◽  
...  

1971 ◽  
Vol 6 (1) ◽  
pp. 41-41
Author(s):  
K. Kera ◽  
S. Nakamura ◽  
T. Aikawa ◽  
K. Sasaki ◽  
T. Nakamura

1997 ◽  
Vol 272 (3) ◽  
pp. G617-G625 ◽  
Author(s):  
A. J. Makin ◽  
R. D. Hughes ◽  
R. Williams

Systemic and hepatic circulatory changes were studied in rats over the course of acute liver injury. Hepatic injury was induced by intraperitoneal injection of D-galactosamine (1.1 g/kg), and systemic and hepatic hemodynamics were measured over a 72-h period using a radioactive microsphere technique with direct measurement of arterial, portal venous, and hepatic venous blood oxygen content. Cardiac output increased to a maximum at 48 h, producing a marked increase (450%) in hepatic arterial blood flow so that it became the dominant supply of oxygen at the time of maximal hepatic injury. A subsequent increase in portal venous flow resulted in an overall increase in total hepatic blood flow of 500%. At this point the oxygen delivery by the hepatic arterial and portal venous systems was equal. These circulatory changes returned to control values by 72 h with recovery of liver function. These results demonstrate the development of a hyperdynamic circulation and a marked change in the normal relationship between portal venous and hepatic arterial blood flows that occur during hepatic injury.


1983 ◽  
Vol 34 (1) ◽  
pp. 17-24 ◽  
Author(s):  
K.V. Stribley ◽  
B.N. Gray ◽  
R.L. Chmiel ◽  
J.C.P. Heggie ◽  
R.C. Bennett

1989 ◽  
Vol 71 (Supplement) ◽  
pp. A306 ◽  
Author(s):  
P. Wouters ◽  
M-F. Doursout ◽  
S. Kashimoto ◽  
C. Lawrence ◽  
R. G. Merin ◽  
...  

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