Effects of Nonsteroidal Antiinflammatory Drugs on Renal Function in Patients With Renal Insufficiency and in Cirrhotics

1986 ◽  
Vol 8 (5) ◽  
pp. 351-355 ◽  
Author(s):  
D. Craig Brater ◽  
Shirley A. Anderson ◽  
Debbie Brown-Cartwright ◽  
Robert D. Toto
Keyword(s):  
Renal Function ◽  
Renal Insufficiency ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs

scholarly journals Effects of nonsteroidal antiinflammatory drugs on renal function in sickle cell anemia

1988 ◽  
Vol 34 (4) ◽  
pp. 500-506 ◽  
Author(s):  
Michael Allon ◽  
Lydia Lawson ◽  
James R. Eckman ◽  
Vera Delaney ◽  
Edmund Bourke
Keyword(s):  
Renal Function ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs

Renal Insufficiency Associated with Intramuscular Administration of Ketorolac Tromethamine

1993 ◽  
Vol 27 (9) ◽  
pp. 1055-1057 ◽  
Author(s):  
Robin L. Corelli ◽  
Kristin R. Gericke
Keyword(s):  
Renal Insufficiency ◽  
Renal Toxicity ◽  
Adverse Drug Reaction Reporting ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Ketorolac Tromethamine ◽  
Antiinflammatory Drugs ◽  
Narcotic Analgesics ◽  
Term Administration ◽  
The Mean ◽  
Peak Value

OBJECTIVE: To evaluate reports of renal toxicity associated with intramuscular ketorolac tromethamine. Medical charts were reviewed for all cases of renal toxicity associated with ketorolac therapy. METHODS: Patients with possible ketorolac-associated nephrotoxicity were identified through our institution's adverse drug reaction reporting program. Patients were included in this report if: (1) renal insufficiency was temporally related to ketorolac administration; (2) resolution of renal insufficiency occurred after discontinuation of ketorolac; and (3) no other causes of renal insufficiency, including other medications, could be identified. RESULTS: Six patients had renal insufficiency secondary to ketorolac administration. The mean age of the patients was 58 years and cardiovascular disease was present in five. Serum creatinine values increased from a mean of 106 ± 26 μmol/L (1.2 ± 0.3 mg/dL) to a mean peak value of 256 ± 195 μmol/L (2.9 ± 2.2 mg/dL). Recovery of renal function was observed after a mean of 2.3 ± 0.5 days. CONCLUSIONS: Short-term administration of ketorolac can be associated with reversible oliguric renal insufficiency. Indiscriminate use of ketorolac for pain management in place of narcotic analgesics should be avoided, especially in patients at high risk for toxicity induced by nonsteroidal antiinflammatory drugs.

T3 concentrations reflect renal function in patients with renal insufficiency

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
W Reinhardt ◽  
U Ewerhart ◽  
K Mann ◽  
O Witzke
Keyword(s):  
Renal Function ◽  
Renal Insufficiency
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