Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00113a022 ◽

1991 ◽

Vol 34 (9) ◽

pp. 2824-2836 ◽

Author(s):

T. A. Andrea ◽

Hooshmand Kalayeh

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Evolutionary Neural Networks in Quantitative Structure-Activity Relationships of Dihydrofolate Reductase Inhibitors

Quantitative Structure-Activity Relationships ◽

10.1002/qsar.19960150404 ◽

1996 ◽

Vol 15 (4) ◽

pp. 296-301 ◽

Author(s):

Jari KyngÃ¤s ◽

Jarkko Valjakka

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Evolutionary Neural Networks ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Quantitative Structure Activity Relationships of Dihydrofolate Reductase Inhibitors by Neural Networks

Protein Engineering Design and Selection ◽

10.1093/protein/6.supplement.107-b ◽

1993 ◽

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS BY DISTANCE GEOMETRY: SYSTEMATIC ANALYSIS OF DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198042296 ◽

1980 ◽

Vol 11 (42) ◽

Author(s):

G. M. CRIPPEM

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure ◽

Systematic Analysis ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Quantitative structure-activity relationships by distance geometry: systematic analysis of dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00180a004 ◽

1980 ◽

Vol 23 (6) ◽

pp. 599-606 ◽

Author(s):

Gordon M. Crippen

Keyword(s):

Dihydrofolate Reductase ◽

Distance Geometry ◽

Quantitative Structure ◽

Systematic Analysis ◽

Structure Activity Relationships ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: USE OF PHYSICOCHEMICAL PARAMETERS IN DISTANCE GEOMETRY AND RELATED THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS: A DEMONSTRATION USING ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE INHIBITORS

Chemischer Informationsdienst ◽

10.1002/chin.198532378 ◽

1985 ◽

Vol 16 (32) ◽

Author(s):

A. K. GHOSE ◽

G. M. CRIPPEN

Keyword(s):

Escherichia Coli ◽

Dihydrofolate Reductase ◽

Physicochemical Parameters ◽

Distance Geometry ◽

Three Dimensional ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Use of physicochemical parameters in distance geometry and related three-dimensional quantitative structure-activity relationships: A demonstration using Escherichia coli dihydrofolate reductase inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm00381a013 ◽

1985 ◽

Vol 28 (3) ◽

pp. 333-346 ◽

Author(s):

Arup K. Ghose ◽

Gordon M. Crippen

Keyword(s):

Escherichia Coli ◽

Dihydrofolate Reductase ◽

Physicochemical Parameters ◽

Distance Geometry ◽

Three Dimensional ◽

Quantitative Structure ◽

Reductase Inhibitors ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Dihydrofolate Reductase Inhibitors

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Quantitative structure-activity relationships by neural networks and inductive logic programming. II. The inhibition of dihydrofolate reductase by triazines

Journal of Computer-Aided Molecular Design ◽

10.1007/bf00125376 ◽

1994 ◽

Vol 8 (4) ◽

pp. 421-432 ◽

Author(s):

Jonathan D. Hirst ◽

Ross D. King ◽

Michael J. E. Sternberg

Keyword(s):

Neural Networks ◽

Logic Programming ◽

Dihydrofolate Reductase ◽

Inductive Logic Programming ◽

Inductive Logic ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative structure–activity relationships by evolved neural networks for the inhibition of dihydrofolate reductase by pyrimidines

10.1016/s0303-2647(01)00192-7 ◽

2002 ◽

Vol 65 (1) ◽

pp. 37-47 ◽

Author(s):

Dana G Landavazo ◽

Gary B Fogel ◽

David B Fogel

Keyword(s):

Neural Networks ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative structure-activity relationships by neural networks and inductive logic programming. I. The inhibition of dihydrofolate reductase by pyrimidines

Journal of Computer-Aided Molecular Design ◽

10.1007/bf00125375 ◽

1994 ◽

Vol 8 (4) ◽

pp. 405-420 ◽

Author(s):

Jonathan D. Hirst ◽

Ross D. King ◽

Michael J. E. Sternberg

Keyword(s):

Neural Networks ◽

Logic Programming ◽

Dihydrofolate Reductase ◽

Inductive Logic Programming ◽

Inductive Logic ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure−Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate Reductase†

Journal of Medicinal Chemistry ◽

10.1021/jm970776j ◽

1998 ◽

Vol 41 (22) ◽

pp. 4261-4272 ◽

Author(s):

Cynthia Dias Selassie ◽

Wei-Xi Gan ◽

Lara S. Kallander ◽

Teri E. Klein

Keyword(s):

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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