2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics

2005 ◽  
Vol 48 (22) ◽  
pp. 6956-6969 ◽  
Author(s):  
Alan D. Borthwick ◽  
Dave E. Davies ◽  
Anne M. Exall ◽  
David G. Livermore ◽  
Steve L. Sollis ◽  
...  
Keyword(s):  
Oxytocin Antagonists ◽  
Orally Bioavailable

Pyridyl-2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists: Synthesis, Pharmacokinetics, and In Vivo Potency

2012 ◽  
Vol 55 (2) ◽  
pp. 783-796 ◽  
Author(s):  
Alan D. Borthwick ◽  
John Liddle ◽  
Dave E. Davies ◽  
Anne M. Exall ◽  
Christopher Hamlett ◽  
...  
Keyword(s):  
Oxytocin Antagonists ◽  
Orally Bioavailable

Nonpeptide oxytocin antagonists: Potent, orally bioavailable analogs of L-371,257 containing A 1-R-(pyridyl)ethyl ether terminus

1998 ◽  
Vol 8 (21) ◽  
pp. 3081-3086 ◽  
Author(s):  
Michelle S. Kuo ◽  
Mark G. Bock ◽  
Roger M. Freidinger ◽  
Maribeth T. Guidotti ◽  
Edward V. Lis ◽  
...  
Keyword(s):  
Ethyl Ether ◽  
Oxytocin Antagonists ◽  
Orally Bioavailable

2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 3. Synthesis, Pharmacokinetics, and in Vivo Potency

2006 ◽  
Vol 49 (14) ◽  
pp. 4159-4170 ◽  
Author(s):  
Alan D. Borthwick ◽  
Dave E. Davies ◽  
Anne M. Exall ◽  
Richard J. D. Hatley ◽  
Jennifer A. Hughes ◽  
...  
Keyword(s):  
Oxytocin Antagonists ◽  
Orally Bioavailable

Orally bioavailable nonapeptide oxytocin antagonists

Peptides 1994 ◽  
1995 ◽  
pp. 708-709
Author(s):  
D. W. Hobbs ◽  
P. D. Williams ◽  
N. P. Gould ◽  
J. B. Hoffman ◽  
D. F. Veber ◽  
...  
Keyword(s):  
Oxytocin Antagonists ◽  
Orally Bioavailable
Sign in / Sign up

Export Citation Format

Share Document