Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines

Makoto Kamata; Toshiro Yamashita; Toshihiro Imaeda; Toshio Tanaka; Shinichi Masada; Masahiro Kamaura; Shizuo Kasai; Ryoma Hara; Shigekazu Sasaki; Shiro Takekawa; Asano Asami; Tomoko Kaisho; Nobuhiro Suzuki; Shuntaro Ashina; Hitomi Ogino; Yoshihide Nakano; Yasutaka Nagisa; Koki Kato; Kaneyoshi Kato; Yuji Ishihara

doi:10.1021/jm201596h

Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines

Journal of Medicinal Chemistry ◽

10.1021/jm201596h ◽

2012 ◽

Vol 55 (5) ◽

pp. 2353-2366 ◽

Cited By ~ 23

Author(s):

Makoto Kamata ◽

Toshiro Yamashita ◽

Toshihiro Imaeda ◽

Toshio Tanaka ◽

Shinichi Masada ◽

...

Keyword(s):

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.01.104 ◽

2007 ◽

Vol 17 (8) ◽

pp. 2171-2178 ◽

Cited By ~ 8

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Junko Tamiya ◽

Mingzhu Zhang ◽

Brian Dyck ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.06.049 ◽

2006 ◽

Vol 16 (18) ◽

pp. 4922-4930 ◽

Cited By ~ 10

Author(s):

Sarah Hudson ◽

Mehrak Kiankarimi ◽

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Dongpei Wu ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Solid-phase synthesis and structure–activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.07.040 ◽

2006 ◽

Vol 16 (19) ◽

pp. 5066-5072 ◽

Cited By ~ 4

Author(s):

Vu Ma ◽

Anthony W. Bannon ◽

Jamie Baumgartner ◽

Clarence Hale ◽

Faye Hsieh ◽

...

Keyword(s):

Hormone Receptor ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Phase Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Synthesis and Structure—Activity Relationships of Piperidine-Based Melanin-Concentrating Hormone Receptor 1 Antagonists.

ChemInform ◽

10.1002/chin.200642135 ◽

2006 ◽

Vol 37 (42) ◽

Author(s):

Wen-Lian Wu ◽

Duane A. Burnett ◽

Richard Spring ◽

Li Qiang ◽

Thavalakulamgara K. Sasikumar ◽

...

Keyword(s):

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.06.045 ◽

2006 ◽

Vol 16 (17) ◽

pp. 4450-4457 ◽

Cited By ~ 6

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Brian Dyck ◽

Jonathan Grey ◽

Junko Tamiya ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01704 ◽

2016 ◽

Vol 59 (3) ◽

pp. 1116-1139 ◽

Cited By ~ 12

Author(s):

Hideyuki Igawa ◽

Masashi Takahashi ◽

Keiko Kakegawa ◽

Asato Kina ◽

Minoru Ikoma ◽

...

Keyword(s):

Hormone Receptor ◽

Aliphatic Amine ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.04.061 ◽

2006 ◽

Vol 16 (14) ◽

pp. 3668-3673 ◽

Cited By ~ 8

Author(s):

Wen-Lian Wu ◽

Duane A. Burnett ◽

Richard Spring ◽

Li Qiang ◽

Thavalakulamgara K. Sasikumar ◽

...

Keyword(s):

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

Download Full-text

Synthesis and structure–activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.05.015 ◽

2005 ◽

Vol 15 (14) ◽

pp. 3439-3445 ◽

Cited By ~ 14

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Brian Dyck ◽

Junko Tamiya ◽

Mingzhu Zhang ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Correction to Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure–Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00433 ◽

2016 ◽

Vol 59 (7) ◽

pp. 3577-3577

Author(s):

Hideyuki Igawa ◽

Masashi Takahashi ◽

Keiko Kakegawa ◽

Asato Kina ◽

Minoru Ikoma ◽

...

Keyword(s):

Hormone Receptor ◽

Aliphatic Amine ◽

Structure Activity Relationships ◽

Structure Activity ◽

Melanin Concentrating Hormone

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Melanin-concentrating hormone receptor 1 antagonists: Synthesis, structure–activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.09.007 ◽

2011 ◽

Vol 19 (21) ◽

pp. 6261-6273 ◽

Cited By ~ 10

Author(s):

Shizuo Kasai ◽

Masahiro Kamaura ◽

Makoto Kamata ◽

Kazuyoshi Aso ◽

Hitomi Ogino ◽

...

Keyword(s):

Hormone Receptor ◽

Structure Activity Relationship ◽

Docking Studies ◽

Biological Evaluation ◽

Activity Relationship ◽

Structure Activity ◽

Melanin Concentrating Hormone

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