scholarly journals Bornyl- and Isobornyl-Δ8-tetrahydrocannabinols: A Novel Class of Cannabinergic Ligands

2008 ◽  
Vol 51 (20) ◽  
pp. 6393-6399 ◽  
Author(s):  
Dai Lu ◽  
Jianxin Guo ◽  
Richard I. Duclos ◽  
Anna L. Bowman ◽  
Alexandros Makriyannis
Keyword(s):  
Cannabinergic Ligands

Cannabinergic ligands

2002 ◽  
Vol 121 (1-2) ◽  
pp. 3-19 ◽  
Author(s):  
Sonya L. Palmer ◽  
Ganesh A. Thakur ◽  
Alexandros Makriyannis
Keyword(s):  
Cannabinergic Ligands

scholarly journals Controlled-Deactivation Cannabinergic Ligands

2013 ◽  
Vol 56 (24) ◽  
pp. 10142-10157 ◽  
Author(s):  
Rishi Sharma ◽  
Spyros P. Nikas ◽  
Carol A. Paronis ◽  
JodiAnne T. Wood ◽  
Aneetha Halikhedkar ◽  
...  
Keyword(s):  
Cannabinergic Ligands

scholarly journals Novel bicyclic and tricyclic cannabinergic ligands as therapeutic agents

2012 ◽  
Author(s):  
Shama Bajaj
Keyword(s):  
Therapeutic Agents ◽  
Cannabinergic Ligands

scholarly journals Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands

2008 ◽  
Vol 49 (39) ◽  
pp. 5587-5589 ◽  
Author(s):  
Richard I. Duclos ◽  
Dai Lu ◽  
Jianxin Guo ◽  
Alexandros Makriyannis
Keyword(s):  
Synthesis And Characterization ◽  
Cannabinergic Ligands

scholarly journals Biotransformation studies of cannabinergic ligands combining LC/MS and microcoil-NMR

2019 ◽  
Author(s):  
Chandrashekhar Honrao
Keyword(s):  
Microcoil Nmr ◽  
Cannabinergic Ligands

scholarly journals Functional Activity and Switching of Novel Cannabinergic Ligands

2015 ◽  
Author(s):  
Bret Koertge
Keyword(s):  
Functional Activity ◽  
Cannabinergic Ligands

Old Strategies and New Perspectives in Modulating the Endocannabinoid System

2019 ◽  
Vol 15 (2) ◽  
pp. 159-173 ◽  
Author(s):  
Brizzi Antonella ◽  
Pessina Federica
Keyword(s):  
Drug Targets ◽  
Pharmaceutical Research ◽  
Endocannabinoid System ◽  
Natural World ◽  
Endogenous Lipid ◽  
Leading Position ◽  
Unique Source ◽  
Main Components ◽  
Cannabinergic Ligands ◽  
Important Drug

Endocannabinoid System (ES) has gained over the years a leading position in scientific research thanks to its involvement in numerous patho/physiological conditions. Accordingly, its main components, such as receptors, enzymes and mediators, have become important drug targets for the management of diseases where it is dysregulated. Within the manuscript, several classes of cannabinergic ligands are examined, emphasizing molecules coming from the natural world, unique source of active compounds. Firstly, the endogenous lipid ES modulators are described, starting from the major endocannabinoids to the plethora of endocannabinoid congeners. Afterwards, Cannabis-derived cannabinoids, namely well-known phytocannabinoids and new constituents from different varieties of Cannabis, are reviewed also mentioning the huge effort of pharmaceutical research in obtaining synthetic analogues. Finally, an overview of peptides and miscellaneous natural products points out new opportunities to modulate ES, offering an enormous chemical heterogeneity. Accordingly, hemopressin and related peptides, plant-derived alkylamides, terpenoid derivatives, neolignans and examples from the marine world can provide interesting hints and original ideas to develop new cannabinergic compounds.

How lipophilic cannabinergic ligands reach their receptor sites

2005 ◽  
Vol 77 (1-4) ◽  
pp. 210-218 ◽  
Author(s):  
Alexandros Makriyannis ◽  
Xiaoyu Tian ◽  
Jianxin Guo
Keyword(s):  
Receptor Sites ◽  
Cannabinergic Ligands

Methods for the Synthesis of Cannabinergic Ligands

2006 ◽  
pp. 113-148
Author(s):  
Ganesh A. Thakur ◽  
Spyros P. Nikas ◽  
Richard I. Duclos ◽  
Alexandros Makriyannis
Keyword(s):  
Cannabinergic Ligands
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