functional activity
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2022 ◽  
Xu Yang ◽  
Zhe-Yuan Li ◽  
Li-Hong Si ◽  
Bo Shen ◽  
Xia Ling

Abstract The study aimed to investigate resting-state functional brain activity alterations in patients with definite vestibular migraine (dVM). Seventeen patients with dVM, 8 patients with migraine, 17 health controls (HCs) were recruited. The amplitude of low frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) were calculated to observe the changes in spontaneous brain activity. Then brain regions with altered fALFF were selected for seed-based functional connectivity analysis. Compared with HCs, VM patients showed significantly increased ALFF values in the right temporal lobe (Cluster size = 91 voxels, P=0.002, FWE corrected), and significantly increased ReHo values in the right superior temporal gyrus (STG), middle temporal gyrus (MTG) and inferior temporal gyrus (ITG) (Cluster size = 136 voxels, P=0.013, FWE corrected). Compared with patients with migraine, patients with VM showed significantly increased fALFF values in the right parietal lobe (Cluster size = 43 voxels, P=0.011, FWE corrected) and right frontal lobe (Cluster size =36 voxels, P=0.026, FWE corrected), significantly increased ReHo values in the right thalamus (Cluster size = 92 voxels, P=0.043, FWE corrected). Our findings documented that patients with VM showed enhanced spontaneous functional activity in the right temporal lobe (STG, MTG, and ITG) compared with HCs, and increased spontaneous activity in the right parietal lobe-frontal lobe-thalamus compared with patients with migraine. Patients with VM and migraine both had altered brain function, but the regions involved are different.

2022 ◽  
Vol 12 ◽  
A. I. Chekunova ◽  
S. Yu. Sorokina ◽  
E. A. Sivoplyas ◽  
G. N. Bakhtoyarov ◽  
P. A. Proshakov ◽  

As assemblies of genomes of new species with varying degrees of relationship appear, it becomes obvious that structural rearrangements of the genome, such as inversions, translocations, and transposon movements, are an essential and often the main source of evolutionary variation. In this regard, the following questions arise. How conserved are the regulatory regions of genes? Do they have a common evolutionary origin? And how and at what rate is the functional activity of genes restored during structural changes in the promoter region? In this article, we analyze the evolutionary history of the formation of the regulatory region of the ras85D gene in different lineages of the genus Drosophila, as well as the participation of mobile elements in structural rearrangements and in the replacement of specific areas of the promoter region with those of independent evolutionary origin. In the process, we substantiate hypotheses about the selection of promoter elements from a number of frequently repeated motifs with different degrees of degeneracy in the ancestral sequence, as well as about the restoration of the minimum required set of regulatory sequences using a conversion mechanism or similar.

N. V. Efanova ◽  
S. V. Batalova ◽  
L. M. Osina ◽  
Е. D. Naumova

   The article presents data on the breed and seasonal characteristics of the synthesis of thyroxine and cortisol in dogs of different breeds and cats that do not have a breed. It has been shown that the synthesis of thyroxine in dogs and cats depends on the breed, age and season. The functional activity of the thyroid gland in dogs decreases by 10-12, and in cats by 9-13 years of age. The highest level of thyroxine production throughout the entire research period belongs to the Griffon Petit-Brabancons. The synthesis of cortisol in dogs and cats is stable and does not undergo statistically significant changes. Seasonal dynamics of thyroxine is observed in dogs, but absent in cats. No sea-sonal dependence of cortisol synthesis has been reported in dogs and cats.

Ika Rosdiana ◽  
Verina Gian Daniswari ◽  
Getri Sura ◽  
- Ariestiani

International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 30-35

2021 ◽  
Vol 26 (2(49)) ◽  
pp. 89-97
R. V. Yanko

Introduction: Despite the well-studied effect of alimentary deprivation on the body, the literature data on its effect on functional activity and, in particular, on morphological changes in the thyroid gland are single and often contradictory, which does not allow unambiguous conclusions. All this requires a more detailed study of the role and mechanisms of the impact of restricted nutrition on the thyroid gland. Aim: To investigate the effect of alimentary deprivation on morphological changes in the thyroid gland of young rats. Methods: The study was conducted on 24 male Wistar rats aged 3 months. Rats of all groups were in uniform conditions, on a standard diet. Animals of the experimental group, for 28 days, received a diet reduced by 30 %. Work with rats was carried out in accordance with the principles of the Declaration of Helsinki. Histological preparations were made from the central areas of the thyroid tissue according to the standard method. Using a digital camera, the micropreparations were photographed under a Nikon Eclipse E 100 microscope (Japan). Morphometry was performed using a computer program "Image J". Results: Histological analysis of the rat's thyroid gland affected by alimentary deprivation revealed that it had an unchanged physiological structure. The follicles were mostly of oval shape and of various sizes. Colloid in the follicles of experimental animals is of moderate density and contains numerous resorption vacuoles. Thyroid cells are of prismatic and cubic shape. It was found that in the thyroid gland of experimental rats the area of ​​follicles, colloid, their inner diameter decreases, the height of thyrocytes increases, the stereological resorption index increases and the colloid accumulation index decreases, the number of interfollicular islands increases. Also in experimental animals there was a decrease in the width of the interlobar and interfollicular connective tissue. Conclusion: In rats fed on a reduced diet, morphological signs of increased functional activity of the thyroid gland were found.

O. V. Zlobina ◽  
V. F. Kirichuk ◽  
S. S. Pakhomii ◽  
A. N. Ivanov ◽  
A. Yu. Karetnikova ◽  

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