Determination of Absolute Configuration in Molecules with Chiral Axes by Vibrational Circular Dichroism:  A C2-Symmetric Annelated Heptathiophene and a D2-Symmetric Dimer of 1,1‘-Binaphthyl

2003 ◽  
Vol 107 (39) ◽  
pp. 7692-7696 ◽  
Author(s):  
Teresa B. Freedman ◽  
Xiaolin Cao ◽  
Andrzej Rajca ◽  
Hua Wang ◽  
Laurence A. Nafie
Keyword(s):  
Circular Dichroism ◽  
Absolute Configuration ◽  
Vibrational Circular Dichroism ◽  
Determination Of Absolute Configuration ◽  
Circular Dichroïsm

scholarly journals Vibrational Circular Dichroism: A New Tool for the Solution-State Determination of the Structure and Absolute Configuration of Chiral Natural Product Molecules

2008 ◽  
Vol 3 (3) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Laurence A. Nafie
Keyword(s):  
Circular Dichroism ◽  
Natural Product ◽  
Absolute Configuration ◽  
Vibrational Circular Dichroism ◽  
Chiral Molecules ◽  
Solution State ◽  
X Ray Crystallography ◽  
Determination Of Absolute Configuration ◽  
Circular Dichroïsm

Vibrational circular dichroism (VCD) has been used in recent years to determine the absolute configuration of a number of natural product chiral molecules. In this brief review, these applications will be described and the methodology of VCD determination of absolute configuration (AC) will be explained. The principal advantages of VCD versus X-ray crystallography for absolute configuration determination are: 1) only solution-state samples are needed and therefore single crystals are not required, 2) high enantiomeric sample purity is not required, 3) high chemical purity is not required as long as impurities are not chiral and 4) solution-state conformations are obtained as an extra feature of the AC determination.

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