Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

2009 ◽  
Vol 22 (2) ◽  
pp. 332-340 ◽  
Author(s):  
Jonathon N. Bauman ◽  
Joan M. Kelly ◽  
Sakambari Tripathy ◽  
Sabrina X. Zhao ◽  
Wing W. Lam ◽  
...  
Keyword(s):  
Covalent Binding ◽  
Human Hepatocytes ◽  
In Vitro Metabolism ◽  
Binding Data

In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)–Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes

2013 ◽  
Vol 41 (12) ◽  
pp. 2148-2157 ◽  
Author(s):  
Raman Sharma ◽  
Thomas S. McDonald ◽  
Heather Eng ◽  
Chris Limberakis ◽  
Benjamin D. Stevens ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
In Vitro Metabolism ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals In Vitro Metabolism of 3,4-Methylenedioxymethamphetamine in Human Hepatocytes

2014 ◽  
Vol 38 (5) ◽  
pp. 249-255 ◽  
Author(s):  
Corinne Ramaley ◽  
Susan C. Leonard ◽  
Jeffrey D. Miller ◽  
Denita Takesha-Mashia Wilson ◽  
Sai Y. Chang ◽  
...  
Keyword(s):  
Human Hepatocytes ◽  
In Vitro Metabolism

In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins

1992 ◽  
Vol 228 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Christine Martinat ◽  
Claudine Amar ◽  
Patrick M. Dansette ◽  
Jacques Leclaire ◽  
Pilar Lopez-Garcia ◽  
...  
Keyword(s):  
Covalent Binding ◽  
In Vitro Metabolism

In vitro metabolism of a new cardioprotective agent, KR-33028 in the human liver microsomes and cryopreserved human hepatocytes

2005 ◽  
Vol 28 (11) ◽  
pp. 1287-1292 ◽  
Author(s):  
Hyojin Kim ◽  
Yune -Jung Yoon ◽  
Hyunmi Kim ◽  
Eun -Young Cha ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Microsomes ◽  
Human Hepatocytes ◽  
Human Liver Microsomes ◽  
In Vitro Metabolism

The in vitro metabolism and covalent binding of benzo[a]pyrene to dna catalysed by trout liver microsomes

1979 ◽  
Vol 25 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Jorma T. Ahokas ◽  
Hannu Saarni ◽  
Daniel W. Nebert ◽  
Olavi Pelkonen
Keyword(s):  
Covalent Binding ◽  
Liver Microsomes ◽  
In Vitro Metabolism

scholarly journals Tecarfarin: A New Oral Anticoagulant and the Characterization of its In Vitro Metabolism Using Rat, Dog, and Human Hepatocytes

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Luke Lightning ◽  
Padmapriya Kumaraswamy ◽  
Renee Coleman ◽  
Ian Irwin ◽  
Monica Palme ◽  
...  
Keyword(s):  
Oral Anticoagulant ◽  
Human Hepatocytes ◽  
In Vitro Metabolism ◽  
New Oral Anticoagulant
Sign in / Sign up

Export Citation Format

Share Document