Myosin II functions in actin-bundle turnover in neuronal growth cones

2006 ◽  
Vol 8 (3) ◽  
pp. 216-226 ◽  
Author(s):  
Nelson A. Medeiros ◽  
Dylan T. Burnette ◽  
Paul Forscher
Keyword(s):  
Myosin Ii ◽  
Growth Cones ◽  
Neuronal Growth ◽  
Actin Bundle ◽  
Neuronal Growth Cones

scholarly journals Protein kinase C activation decreases peripheral actin network density and increases central nonmuscle myosin II contractility in neuronal growth cones

2013 ◽  
Vol 24 (19) ◽  
pp. 3097-3114 ◽  
Author(s):  
Qing Yang ◽  
Xiao-Feng Zhang ◽  
David Van Goor ◽  
Ashleigh P. Dunn ◽  
Callen Hyland ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Myosin Ii ◽  
Growth Cones ◽  
Network Density ◽  
Actin Network ◽  
Neuronal Growth ◽  
Kinase C ◽  
Neuronal Growth Cones ◽  
Pkc Activation

Protein kinase C (PKC) can dramatically alter cell structure and motility via effects on actin filament networks. In neurons, PKC activation has been implicated in repulsive guidance responses and inhibition of axon regeneration; however, the cytoskeletal mechanisms underlying these effects are not well understood. Here we investigate the acute effects of PKC activation on actin network structure and dynamics in large Aplysia neuronal growth cones. We provide evidence of a novel two-tiered mechanism of PKC action: 1) PKC activity enhances myosin II regulatory light chain phosphorylation and C-kinase–potentiated protein phosphatase inhibitor phosphorylation. These effects are correlated with increased contractility in the central cytoplasmic domain. 2) PKC activation results in significant reduction of P-domain actin network density accompanied by Arp2/3 complex delocalization from the leading edge and increased rates of retrograde actin network flow. Our results show that PKC activation strongly affects both actin polymerization and myosin II contractility. This synergistic mode of action is relevant to understanding the pleiotropic reported effects of PKC on neuronal growth and regeneration.

scholarly journals Theoretical Model for Optical Guidance of Neuronal Growth Cones

2021 ◽  
Vol 120 (3) ◽  
pp. 170a
Author(s):  
Kahmina R. Ford ◽  
Erin M. Craig
Keyword(s):  
Theoretical Model ◽  
Growth Cones ◽  
Neuronal Growth ◽  
Neuronal Growth Cones

Localization of ganglioside 9-O-acetyl GD3 in point contacts of neuronal growth cones

2003 ◽  
Vol 57 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Erika M. A. Negreiros ◽  
Ana C. M. Leão ◽  
Marcelo F. Santiago ◽  
Rosalia Mendez-Otero
Keyword(s):  
Growth Cones ◽  
Point Contacts ◽  
Neuronal Growth ◽  
Neuronal Growth Cones

scholarly journals Pathfinding by neuronal growth cones in grasshopper embryos. I. Divergent choices made by the growth cones of sibling neurons

1983 ◽  
Vol 3 (1) ◽  
pp. 20-30 ◽  
Author(s):  
JA Raper ◽  
M Bastiani ◽  
CS Goodman
Keyword(s):  
Growth Cones ◽  
Neuronal Growth ◽  
Neuronal Growth Cones

Further characterization of [3H]γ-aminobutyric acid release from isolated neuronal growth cones: Role of intracellular CA2+ stores

Neuroscience ◽  
1986 ◽  
Vol 17 (4) ◽  
pp. 1257-1266 ◽  
Author(s):  
R.O. Lockerbie ◽  
P.R. Gordon-Weeks
Keyword(s):  
Growth Cones ◽  
Aminobutyric Acid ◽  
Neuronal Growth ◽  
Acid Release ◽  
Neuronal Growth Cones

Chick sensory neuronal growth cones distinguish fibronectin from laminin by making substratum contacts that resemble focal contacts

1996 ◽  
Vol 29 (1) ◽  
pp. 18-34 ◽  
Author(s):  
Timothy M. Gomez ◽  
Florence K. Roche ◽  
Paul C. Letourneau
Keyword(s):  
Growth Cones ◽  
Neuronal Growth ◽  
Focal Contacts ◽  
Neuronal Growth Cones

scholarly journals Stimulus History Alters Behavioral Responses of Neuronal Growth Cones

2000 ◽  
Vol 20 (4) ◽  
pp. 1484-1494 ◽  
Author(s):  
Thomas J. Diefenbach ◽  
Peter B. Guthrie ◽  
Stanley B. Kater
Keyword(s):  
Behavioral Responses ◽  
Growth Cones ◽  
Neuronal Growth ◽  
Neuronal Growth Cones

scholarly journals Guidance of neuronal growth cones in the grasshopper embryo. II. Recognition of a specific axonal pathway by the aCC neuron

1986 ◽  
Vol 6 (12) ◽  
pp. 3532-3541 ◽  
Author(s):  
S du Lac ◽  
MJ Bastiani ◽  
CS Goodman
Keyword(s):  
Growth Cones ◽  
Neuronal Growth ◽  
Neuronal Growth Cones

Ultrastructural immunocytochemical localization of B-50/GAP43, a protein kinase C substrate, in isolated presynaptic nerve terminals and neuronal growth cones

1989 ◽  
Vol 18 (4) ◽  
pp. 479-489 ◽  
Author(s):  
M. Van Lookeren Campagne ◽  
A. Beate Oestreicher ◽  
P. M. P. Van Bergen En Henegouwen ◽  
W. H. Gispen
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Growth Cones ◽  
Nerve Terminals ◽  
Immunocytochemical Localization ◽  
Neuronal Growth ◽  
Kinase C ◽  
Presynaptic Nerve Terminals ◽  
Neuronal Growth Cones

scholarly journals A Slipping Clutch in Neuronal Growth Cones Revealed by Transient Single Molecule Interactions between Flowing Actin and N-Cadherin Adhesions

2014 ◽  
Vol 106 (2) ◽  
pp. 357a
Author(s):  
Mikael Garcia ◽  
Cécile Leduc ◽  
Amélie Argento ◽  
Jean-Baptiste Sibarita ◽  
Olivier R. Thoumine
Keyword(s):  
Single Molecule ◽  
Growth Cones ◽  
Neuronal Growth ◽  
Molecule Interactions ◽  
Neuronal Growth Cones
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