Systematic molecular evolution enables robust biomolecule discovery

2021 ◽  
Author(s):  
Erika A. DeBenedictis ◽  
Emma J. Chory ◽  
Dana W. Gretton ◽  
Brian Wang ◽  
Stefan Golas ◽  
...  
Keyword(s):  
Molecular Evolution

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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