CHAPTER 15. Allosteric Modulation of Neuronal Nicotinic Acetylcholine Receptors

Allosterism in Drug Discovery ◽

10.1039/9781782629276-00334 ◽

2016 ◽

pp. 334-359

Author(s):

Mark M. Levandoski ◽

Sivaramakrishna Koganti

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

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Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2014.11.027 ◽

2015 ◽

Vol 91 ◽

pp. 157-168 ◽

Author(s):

Caitlin A. Short ◽

Angela T. Cao ◽

Molly A. Wingfield ◽

Matthew E. Doers ◽

Emily M. Jobe ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

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Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: Lack of mechanism-based evidence for cytotoxicity in PC12 cells and rat primary cortical neurons

Biochemical Pharmacology ◽

10.1016/j.bcp.2009.06.042 ◽

2009 ◽

Vol 78 (7) ◽

pp. 904

Author(s):

Min Hu ◽

Murali Gopalakrishnan ◽

Jinhe Li

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Cortical Neurons ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Primary Cortical Neurons ◽

Nicotinic Acetylcholine

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Allosteric modulation of neuronal nicotinic acetylcholine receptors

Journal of Physiology-Paris ◽

10.1016/s0928-4257(98)80144-7 ◽

1998 ◽

Vol 92 (2) ◽

pp. 89-100 ◽

Author(s):

Bruno Buisson ◽

Daniel Bertrand

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

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Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2009.00474.x ◽

2009 ◽

Vol 158 (8) ◽

pp. 1857-1864 ◽

Author(s):

Min Hu ◽

Murali Gopalakrishnan ◽

Jinhe Li

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Cortical Neurons ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Primary Cortical Neurons ◽

Nicotinic Acetylcholine

Download Full-text

Allosteric modulation of neuronal nicotinic acetylcholine receptors requires inter-subunit movement

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.07.023 ◽

2011 ◽

Vol 82 (8) ◽

pp. 1031

Author(s):

Mark Levandoski ◽

Angela Cao ◽

Molly Wingfield

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

Download Full-text

Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2013.12.017 ◽

2014 ◽

Vol 79 ◽

pp. 420-431 ◽

Author(s):

Paul A. Chrisman ◽

Julie I. Podair ◽

Emily M. Jobe ◽

Mark M. Levandoski

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

Download Full-text

Faculty Opinions recommendation of Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092041.553238 ◽

2007 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Self Administration ◽

Nicotinic Acetylcholine

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Allosteric Modulation of Nicotinic Acetylcholine Receptors: The Concept and Therapeutic Trends

Current Pharmaceutical Design ◽

10.2174/1381612822666160201115341 ◽

2016 ◽

Vol 22 (14) ◽

pp. 1986-1997 ◽

Author(s):

Victor V. Uteshev

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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Functional properties of neuronal nicotinic acetylcholine receptors in the chick retina during development

European Journal of Neuroscience ◽

10.1111/j.1460-9568.2005.04150.x ◽

2005 ◽

Vol 21 (11) ◽

pp. 3182-3188 ◽

Author(s):

Marzia Lecchi ◽

J. Michael McIntosh ◽

Sonia Bertrand ◽

Avinoam B. Safran ◽

Daniel Bertrand

Keyword(s):

Functional Properties ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

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Potentiation and inhibition of subtypes of neuronal nicotinic acetylcholine receptors by Pb2+

European Journal of Pharmacology Molecular Pharmacology ◽

10.1016/0922-4106(95)90082-9 ◽

1995 ◽

Vol 291 (3) ◽

pp. 399-406 ◽

Author(s):

Ruud Zwart ◽

Regina G.D.M. Van Kleef ◽

Jacob M. Milikan ◽

Marga Oortgiesen ◽

Henk P.M. Vijverberg

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine

Download Full-text