A heavy metal- and oxidant-free, one-pot synthesis of pyridines and fused pyridines based on a Lewis acid-catalyzed multicomponent reaction

2014 ◽  
Vol 50 (82) ◽  
pp. 12270-12272 ◽  
Author(s):  
V. P. Alex Raja ◽  
Giammarco Tenti ◽  
Subbu Perumal ◽  
J. Carlos Menéndez

Pyridines and fused pyridines are accessible by a combination of a Lewis acid-catalyzed multicomponent reaction and aromatization involving loss of a 2-furylmethyl chain.

Tetrahedron ◽  
2013 ◽  
Vol 69 (2) ◽  
pp. 647-652 ◽  
Author(s):  
Ningning Wang ◽  
Shuying Cai ◽  
Chao Zhou ◽  
Ping Lu ◽  
Yanguang Wang

ChemInform ◽  
2011 ◽  
Vol 42 (27) ◽  
pp. no-no
Author(s):  
Esther Boess ◽  
Tim Hillringhaus ◽  
Jacqueline Nitsch ◽  
Martin Klussmann

Synthesis ◽  
2018 ◽  
Vol 50 (09) ◽  
pp. 1907-1913 ◽  
Author(s):  
Ke-Hu Wang ◽  
Yulai Hu ◽  
Jianglong Wang ◽  
Yalin Wang ◽  
Yingpeng Su ◽  
...  

A simple and efficient synthetic approach is reported for the synthesis of 5-trifluoromethyl-5-aryl-3-methylidenepyrrolidin-2-ones in moderate to excellent yields via an acid-catalyzed one-pot multicomponent reaction of aromatic trifluoromethyl ketones, acylhydrazines, and ethyl 2-(bromomethyl)acrylate promoted by tin powder. The protocol is operationally simple. The overall process involves allylation and cyclization of the intermediate of acylhydrazones.


2013 ◽  
Vol 19 (15) ◽  
pp. 4686-4690 ◽  
Author(s):  
Christelle Lemus ◽  
Marko Poleschak ◽  
Sophie Gailly ◽  
Marine Desage-El Murr ◽  
Michel Koch ◽  
...  

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