Transition metal-free asymmetric and diastereoselective allylic alkylation using Grignard reagents: construction of vicinal stereogenic centers via kinetic resolution

2014 ◽  
Vol 5 (10) ◽  
pp. 3803-3807 ◽  
Author(s):  
David Grassi ◽  
Alexandre Alexakis
Keyword(s):  
Transition Metal ◽  
Kinetic Resolution ◽  
Grignard Reagents ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Quaternary Centers ◽  
Metal Free ◽  
Stereogenic Centers

The first transition metal-free catalyzed diastereoselective and enantioselective asymmetric allylic alkylation (AAA) has been disclosed leading to the construction of vicinal tertiary/quaternary centers via a kinetic resolution protocol starting from readily available starting materials.

Organocatalyzed Asymmetric Allylic Alkylation of Grignard Reagents

Synfacts ◽  
2007 ◽  
Vol 2007 (3) ◽  
pp. 0306-0306
Author(s):  
A. Hoveyda ◽  
Y. Lee
Keyword(s):  
Grignard Reagents ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation

Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents andN-Chloroamines

2010 ◽  
Vol 12 (7) ◽  
pp. 1516-1519 ◽  
Author(s):  
Takuji Hatakeyama ◽  
Yuya Yoshimoto ◽  
Sujit K. Ghorai ◽  
Masaharu Nakamura
Keyword(s):  
Transition Metal ◽  
Grignard Reagents ◽  
Electrophilic Amination ◽  
Metal Free

ChemInform Abstract: Kinetic Resolution of 2,3-Dihydro-2-substituted 4-Quinolones by Palladium-Catalyzed Asymmetric Allylic Alkylation.

ChemInform ◽  
2010 ◽  
Vol 41 (20) ◽  
Author(s):  
Bai-Lin Lei ◽  
Chang-Hua Ding ◽  
Xiao-Fei Yang ◽  
Xiao-Long Wan ◽  
Xue-Long Hou
Keyword(s):  
Kinetic Resolution ◽  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed
Sign in / Sign up

Export Citation Format

Share Document