Revisiting the adhesion mechanism of mussel-inspired chemistry

Mussel-inspired chemistry has become an ideal platform to engineer a myriad of functional materials, but fully understanding the underlying adhesion mechanism is missing. Particularly, one of the most pivotal questions...

Probing Protein Aggregation at Buried Interfaces: Distinguishing Adsorbed Protein Monomer, Dimer, and Monomer-Dimer Mixture in Situ

Protein adsorption on surfaces greatly impacts many applications such as biomedical materials, anti-biofouling coatings, bio-separation membranes, biosensors, and antibody protein drugs etc. For example, protein drug adsorption on widely used...

wSDTNBI: a novel network-based inference method for virtual screening

In recent years, the rapid development of network-based methods for the prediction of drug-target interactions (DTIs) provides an opportunity for the emergence of a new type of virtual screening (VS),...

Fully Fused Boron-Doped Polycyclic Aromatic Hydrocarbons: Their Synthesis, Structure–Property Relationships, and Self-Assembly Behavior in Aqueous Media

Planarized triarylboranes are attracting increasing attention not only as models of boron-doped graphenes, but also as promising materials for organic optoelectronics. In particular, polycyclic aromatic hydrocarbon (PAH) skeletons with embedded...

Controlling the Optical and Catalytic Properties of Artificial Metalloenzyme Photocatalysts Using Chemogenetic Engineering

Visible light photocatalysis enables a broad range of organic transformations that proceed via single electron or energy transfer. Metal polypyridyl complexes are among the most commonly employed visible light photocatalysts....

Polyoxometalates as chemically and structurally versatile components in self-assembled materials

Polyoxometalates (POMs) are anionic molecular metal oxides with expansive diversity in terms of their composition, structure, nuclearity and charge. Within this vast collection of compounds are dominant structural motifs (POM...

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm, e.g. CsgA (E. coli) and FapC (Pseudomonas), is carefully regulated. However, it is unclear whether functional aggregation...

Sequence-Independent Activation of Photocyloadditions Using Two Colors of Light

We exploit two reactive chromophores to establish sequence-independent photochemical activation, employing ortho-methyl benzaldehyde (oMBA) and N,N-(dimethylamino)pyrene aryl tetrazole (APAT) with N-(2-hydroxy)ethyl maleimide (NHEM), without any additives. Critically, the order of...

Single-atom cobalt-hydroxyl modification of polymeric carbon nitride for highly enhanced photocatalytic water oxidation: ball milling increased single atom loading

Expediting the oxygen evolution reaction (OER) is the key to achieving efficient photocatalytic overall water splitting. Herein, single-atom Co−OH modified polymeric carbon nitride (Co-PCN) was synthesized with single-atom loading increased...

Kinetic Trapping of a Cobalt(II) Metallocage using an Carbazole-Containing Expanded Carbaporphyrinoid Ligand

The meso-unsubstituted expanded porphyrinoid 3, incorporating two carbazole moieties, acts as an effective ligand for Co(II) and permits the isolation and X-ray diffraction-based characterization of a 6:3 metal-to-ligand metallocage complex...