Addition reactions of heterocyclic compounds. Part XLVI. Reactions of acetylenic esters with pyridines in the presence of proton donors, and with alkyl 3-(2-pyridyl)-trans-acrylates

1971 ◽  
pp. 3296 ◽  
Author(s):  
R. M. Acheson ◽  
J. Mck. Woollard
Keyword(s):  
Heterocyclic Compounds ◽  
Addition Reactions ◽  
Acetylenic Esters ◽  
Proton Donors

Oxa-michael addition reactions of 3-hydroxy-2-azetidinones: synthesis of 1,3,4-trisubstituted-2-azetidinones

2021 ◽  
Vol 18 ◽  
Author(s):  
Priyanka Sharma ◽  
Maninderjeet Kaur Mann ◽  
Gaurav Bhargava
Keyword(s):  
Michael Addition ◽  
Heterocyclic Compounds ◽  
Addition Reactions ◽  
Reaction Conditions ◽  
Acetylenic Esters

: The manuscript describes a facile and efficient methodology for the synthesis of 1,3,4- trisubstituted-β-lactams by base mediated oxa-Michael addition reactions of 3-hydroxy-2-azetidinones with acetylenic esters under different reaction conditions. These functionalized 1,3,4-trisubstituted-azetidin-2-ones are useful organic synthons for the synthesis of various heterocyclic compounds having diverse pharmacological applications.

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