heterocyclic compounds
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2022 ◽  
Vol 19 ◽  
Pannala Padmaja ◽  
Subba Reddy ◽  
Vinod G. Ugale ◽  
Pedavenkatagari Narayana Reddy

Background: Objective: Objective: biological science.: Background: Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives and spirocyclic compounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, Objective: The aim of this review is to highlight the preparation methods and reactions of arylidenemalononitriles in the synthesis of various heterocyclic compounds. Conclusion: n this review, we have presented the application of arylidenemalononitriles to construct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.

2022 ◽  
Vol 0 (0) ◽  
Sunil Kumar ◽  
Madhuri T. Patil ◽  
Deepak B. Salunke

Abstract Cancer weakens the immune system which fails to fight against the rapidly growing cells. Among the various types of cancers, prostate cancer (PCa) is causing greater number of deaths in men after lung cancer, demanding advancement to prevent, detect and treat PCa. Several small molecule heterocycles and few peptides are being used as oncological drugs targeting PCa. Heterocycles are playing crucial role in the development of novel cancer chemotherapeutics as well as immunotherapeutics. Indole skeleton, being a privileged structure has been extensively used for the discovery of novel anticancer agents and the application of indole derivatives against breast cancer is well documented. The present article highlights the usefulness of indole linked heterocyclic compounds as well as the fused indole derivatives against prostate cancer.

2022 ◽  
Vol 26 ◽  
Zohreh Kheilkordi ◽  
Ghodsi Mahammadi Ziarani ◽  
Fatemeh Mohajer

Abstract: Propellanes and derivatives have attractive properties due to their unique structure. Therefore, [3.3.3] propellanes, containing tricyclic structures with one of the carbon-carbon bonds common in three rings, were used in natural products, pharmaceutical compounds, and heterocyclic compounds, which were biologically important. The various multi-component reactions were applied in the synthesis of propellanes, which were highlighted throughout this review

2022 ◽  
Vol 2022 ◽  
pp. 1-50
Mahrokh Marzi ◽  
Mojtaba Farjam ◽  
Zahra Kazeminejad ◽  
Abolfazl Shiroudi ◽  
Amin Kouhpayeh ◽  

A pharmacophore system has been found as 1,2,3-triazole, a five-membered heterocycle ring with nitrogen heteroatoms. These heterocyclic compounds can be produced using azide-alkyne cycloaddition processes catalyzed by ruthenium or copper. The bioactive compounds demonstrated antitubercular, antibacterial, anti-inflammatory, anticancer, antioxidant, antiviral, and antidiabetic properties. This heterocycle molecule, in particular, with one or more 1,2,3-triazole cores has been found to have the most powerful antifungal effects. The goal of this review is to highlight recent developments in the synthesis and structure-activity relationship (SAR) investigation of this prospective fungicidal chemical. Also there have been explained drugs and mechanism of action of a triazole compound with antifungal activity. This review will be useful in a variety of fields, including medicinal chemistry, organic chemistry, mycology, and pharmacology.

2022 ◽  
Vol 1048 ◽  
pp. 227-238
P. Priyanka ◽  
S. Sivapriya ◽  
M. Gopalakrishnan ◽  
S. Pazhamalai ◽  
M. Seenivasan ◽  

s Heterocyclic compounds like pyrazoline was synthesized along to the reaction of phenyl hydrazine hydrochloride with 3-(benzo [c][1,2,5] oxadiazol-4-yl)-1-phenylprop-2-en-1-one undergoing in reflux condition. This compound going to begood yields.A thoroughly fresh compound wasindicating by IR, 1H, and 13C elemental analysis. Stimulate the calculated HOMO/LUMO, MEP and mulliken population analysis and NLO was compare to the experimental analysis of this data. The optimized theoretical structure parameters betide collate to the satisfied assent with the experimental structure. Keywords: Pyrazoline, Heterocycles, NLO, HOMO/LUMO, Optimized structure, Mulliken charges. Graphical Abstract

Mu-Xue He ◽  
Yan Yao ◽  
Chun-Zhi Ai ◽  
Zu-yu Mo ◽  
Yu-Zheng Wu ◽  

C-H functionalization of allenes is an available strategy to construct heterocyclic compounds. Herein we propose a sus-tainable electrocatalytic C-H activation for the synthesis of novel highly functionalized tetrasubstituted furans, which...

2022 ◽  
Niraj Kumar Vishwakarma ◽  
Shikha Singh ◽  
Sambhav Vishwakarma ◽  
Ajay Kumar Shahi ◽  
Vijay K. Patel ◽  

Solid supported catalysts such as amines has high demand for chemical fixation of CO2 into commodity chemicals. Here, we demonstrate an accelerated platform for 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-ionic liquids (ILs) catalyzed CO2...

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