Granuloma Annulare in the Hand

A review of our cases of granuloma annulare in the hand revealed that it presented as either an annular or subcutaneous lesion, most commonly on the dorsum of the metacarpophalangeal joint of the middle or ring fingers. Lesions were approximately 10 mm in diameter and the diagnosis was confirmed by surgical biopsy. The majority of cases resolved spontaneously within 1 year, and recurrence, though common, did not necessitate a further biopsy.

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ATYPICAL SUBCUTANEOUS GRANULOMA ANNULARE ON THE DIGIT: A CASE REPORT

Hand Surgery ◽

10.1142/s0218810414720228 ◽

2014 ◽

Vol 19 (02) ◽

pp. 257-259

Author(s):

Kazufumi Sano ◽

Kazumoto Katagiri ◽

Satoru Ozeki

Keyword(s):

Case Report ◽

Middle Finger ◽

Definitive Diagnosis ◽

Spontaneous Resolution ◽

Granuloma Annulare ◽

Inflammatory Disorder ◽

Surgical Biopsy ◽

Subcutaneous Nodules ◽

Multiple Nodules

Subcutaneous granuloma annulare is a benign inflammatory disorder consisting of deep dermal or subcutaneous nodules, and frequently occurring in the extremities and scalp in children. The occurrence of aggregated multiple nodules in a digit is quite atypical. This is a report of an eight-year-old girl who presented with increasingly asymptomatic multiple nodules on her middle finger over a period of six months. Definitive diagnosis of subcutaneous granuloma annulare was achieved with surgical biopsy and no aggressive growth subsequently and showed a tendency toward spontaneous resolution.

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The Ultrastructure of Metastatic Human Mammary Carcinoma After Prolonged Estrogen Therapy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010006091x ◽

1967 ◽

Vol 25 ◽

pp. 180-181

Author(s):

John H.L. Watson ◽

John L. Swedo ◽

R.W. Talley

Keyword(s):

Mammary Carcinoma ◽

Osmium Tetroxide ◽

Estrogen Therapy ◽

Ultrastructural Level ◽

Uranyl Acetate ◽

Human Mammary Carcinoma ◽

Surgical Biopsy ◽

Lead Hydroxide ◽

Preliminary Study ◽

Hormonal Therapies

A preliminary study of human mammary carcinoma on the ultrastructural level is reported for a metastatic, subcutaneous nodule, obtained as a surgical biopsy. The patient's tumor had responded favorably to a series of hormonal therapies, including androgens, estrogens, progestins, and corticoids for recurring nodules over eight years. The pertinent nodule was removed from the region of the gluteal maximus, two weeks following stilbestrol therapy. It was about 1.5 cms in diameter, and was located within the dermis. Pieces from it were fixed immediately in cold fixatives: phosphate buffered osmium tetroxide, glutaraldehyde, and paraformaldehyde. Embedment in each case was in Vestopal W. Contrasting was done with combinations of uranyl acetate and lead hydroxide.

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