rheumatoid arthritis
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2022 ◽  
Vol 26 ◽  
pp. 101351
Wenbo Geng ◽  
Maowen Chen ◽  
Bailong Tao ◽  
Rong Wang ◽  
Dong Wang ◽  

2022 ◽  
Vol 12 (4) ◽  
pp. 724-730
Xue Zhong ◽  
Yuebo Jin ◽  
Yufei Feng

Aim: To discuss Muscone treatment in Rheumatoid Arthritis Rat Models and relative mechanisms. Materials and methods: Dividing 36 rats as 4 groups as Normal, Model, DMSO and Muscone groups (n = 9). Rats of Model, DMSO and Muscone groups were made Rheumatoid Arthritis model. Muscone group were treated with 2 mg/kg Muscone after modeling. HE staining and Masson staining were used to observe the morphological changes of cartilage tissue, measuring MMP-3 and MMP-9 expression by RT-PCR, Western Blotting (WB) and Immunohistochemistry (IHC). Results: Compared with Model group, the pathological changes of Muscone group was significantly improved and average optical density of collagen fibers was significantly depressed (P < 0.001, respectively) via MMP-3 and MMP-9 proteins significantly depressing (P < 0.001, respectively). Conclusion: Muscone improved Rheumatoid Arthritis by depressing MMP-3 and MMP-9 proteins in vivo study.

2022 ◽  
Vol 44 (3) ◽  
pp. 185-190
Mona H. Abd Elsamea ◽  
Safaa A. Mahran ◽  
Asmaa N. Badr ◽  
Dalia T. Kamal ◽  
Tayseer M. Khidre

2022 ◽  
Vol 44 (3) ◽  
pp. 203-208
Hanan M. Fathi ◽  
Rozan E. Khalil ◽  
Marwa H. Abo Omirah ◽  
Ahmed Hamdy ◽  
Noha K. Abdelghaffar ◽  

2022 ◽  
Vol 44 (2) ◽  
pp. 115-119
Marina W. Gerges ◽  
Eman A. Hafez ◽  
Reem A. Habeeb ◽  
Hossam M. Sakr ◽  
Nashwa A. Morshedy ◽  

2022 ◽  
Vol 12 (5) ◽  
pp. 939-946
Liangbang Wu ◽  
Zui Wang ◽  
Zhenhai Hou ◽  
Longbao Zheng ◽  
Zenghui Gu

We aimed to explore the mechanism underlying microRNA-23-5p from exosomes (exo-miR-23-5p) of BMSCs in rheumatoid arthritis (RA). The candidate related genes of miR-23-5p were screened in RA by bioinformatics analysis through gain- and loss-function method along with analysis of histopathological changes in mice and RAC2 expression as well as the level of pro-inflammatory factors. In vivo RA model was established to detect miR-23-5p’s effect on RA. miR-23-5p level was significantly reduced in RA cells and RAC2 was highly expressed. Expression of RAC2 was inhibited and targeted by miR-23-5p in RA. Exo-miR-23-5p treatment effectively alleviated joint destruction, reduced inflammatory factor secretion in tissues and serum, as well as decreased RAC2 expression in RA model. In conclusion, the miR-23-5p in the BMSC-exo delays the inflammatory response in RA, indicating that it might be a new target for treating RA.

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