Chiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactions
We synthesized a series of phosphine–olefin-type chiral aminophosphines, and we confirmed that these each exists as two rotamers at the C(aryl)–N(amine) bond. We also investigated the ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asymmetric allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles, and we found they gave high enantioselectivities (up to 98% ee).
Keyword(s):
2002 ◽
Vol 43
(44)
◽
pp. 7867-7869
◽
Keyword(s):
2005 ◽
Vol 347
(15)
◽
pp. 1943-1947
◽
Keyword(s):
2000 ◽
Vol 41
(23)
◽
pp. 4615-4618
◽
1999 ◽
Vol 64
(26)
◽
pp. 9374-9380
◽
Keyword(s):
2005 ◽
Vol 347
(15)
◽
pp. 1893-1898
◽