Enantioselective Addition of Terminal Alkynes to Unactivated Ketones

2011 ◽  
pp. 1
Author(s):  
E. M. Carreira ◽  
D. E. Frantz
Author(s):  
Elena Prieto ◽  
Rebeca Infante ◽  
Javier Nieto ◽  
Celia Andres

A conformationally restricted perhydro-1,3-benzoxazine derived from (-)-8-aminomenthol behaves as a good chiral ligand in the dimethylzinc-mediated enantioselective monoaddition of aromatic and aliphatic terminal alkynes to 1,2-diketones. The corresponding α-hydroxyketones were...


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