Abstract. In this research, reliability indicators of water distribution networks are evaluated under pipe failure conditions. The case studies include two benchmark and one real-life water distribution networks in Iran with more hydraulic constraints. Some important reliability indicators are presented such as resilience index, network resilience, modified resilience index and minimum surplus head index. GANetXL is used to do one-objective and two-objective optimization of the previously mentioned water distribution networks in order to not only minimize the cost, but also maximize the reliability indicators. Moreover, the results of a statistical analysis for each pipe is used to determine the sensitive pipes that are of the most failure probability. GANetXL is an optimization tool in Excel environment and works based on Genetic Algorithm. GANetXL has the capability of being linked to EPANET (Hydraulic simulation software). The results obtained clearly show that network resilience index is of poor performance when compared with the other indexes under pipe failure conditions, especially in real-life networks that include small pipe diameters. It was also showed that if a water distribution network was optimized only in terms of cost, there would be an unacceptable pressure drop at some nodes in case of pipe failure.