Does choroid plexus tumour differ with age?

We present a case of a preterm boy (born at 35 weeks of pregnancy) who was delivered urgently by a caesarean section due to placental abruption. The baby was found to have a tense fontanelle leading to imaging that showed a 5.5 cm right intraventricular mass centred in the atrium, hydrocephalus and extensive surrounding vasogenic oedema. The mass was avidly enhancing with a few large associated vessels suggesting high vascularity. The condition of the baby was acutely deteriorating. He had multiple seizures followed by persistent low level of consciousness in the third day of life. His clinical decline prompted decision to proceed with surgical resection and preoperative embolization. A large single feeder (the right posterolateral choroidal artery) was embolized leading to near complete obliteration of the tumour blush. Embolization likely facilitated subsequent surgery the next day. This is based on an estimated blood loss of 250 ml in this 3 kg baby without haemodynamic instability. Gross total resection was achieved with a single surgery and the diagnosis was choroid plexus papilloma. Utilization of this combined approach in this preterm baby had led to survival in this potentially curable disease.

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Faculty Opinions recommendation of Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726228261.793516901 ◽

2016 ◽

Author(s):

Chaya Kalcheim

Keyword(s):

Choroid Plexus ◽

Sonic Hedgehog ◽

Tumour Cells ◽

Choroid Plexus Tumour

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Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells

Nature Cell Biology ◽

10.1038/ncb3327 ◽

2016 ◽

Vol 18 (4) ◽

pp. 418-430 ◽

Cited By ~ 34

Author(s):

Li Li ◽

Katie B. Grausam ◽

Jun Wang ◽

Melody P. Lun ◽

Jasmin Ohli ◽

...

Keyword(s):

Choroid Plexus ◽

Sonic Hedgehog ◽

Tumour Cells ◽

Choroid Plexus Tumour

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Von Hippel-Lindau disease associated with an invasive choroid plexus tumour presenting as a middle ear mass

The Journal of Laryngology & Otology ◽

10.1017/s0022215100119747 ◽

1992 ◽

Vol 106 (5) ◽

pp. 429-435 ◽

Cited By ~ 26

Author(s):

T. L. Blamires ◽

I. Friedmann ◽

D. A. Moffat

Keyword(s):

Choroid Plexus ◽

Middle Ear ◽

Von Hippel Lindau ◽

Von Hippel Lindau Disease ◽

Choroid Plexus Tumour

AbstractCerebellar haemangioblastomata and angiomata of the retina are the most common vascular tumours seen in von Hippel-Lindau disease. A definite association between this condition and choroid plexus tumour has not been described previously and its presentation as a middle ear mass is unique.

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Organization of tight junctions in the choroid plexus epithelium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100082546 ◽

1978 ◽

Vol 36 (2) ◽

pp. 336-337

Author(s):

B. Van Deurs ◽

J. K. Koehler

Keyword(s):

Choroid Plexus ◽

Present Report ◽

Freeze Fracture ◽

Barrier Properties ◽

Cell Junctions ◽

Structural Basis ◽

Apical Surface ◽

Choroid Plexus Epithelium ◽

Solid Nitrogen ◽

Special Composition

The choroid plexus epithelium constitutes a blood-cerebrospinal fluid (CSF) barrier, and is involved in regulation of the special composition of the CSF. The epithelium is provided with an ouabain-sensitive Na/K-pump located at the apical surface, actively pumping ions into the CSF. The choroid plexus epithelium has been described as “leaky” with a low transepithelial resistance, and a passive transepithelial flux following a paracellular route (intercellular spaces and cell junctions) also takes place. The present report describes the structural basis for these “barrier” properties of the choroid plexus epithelium as revealed by freeze fracture.Choroid plexus from the lateral, third and fourth ventricles of rats were used. The tissue was fixed in glutaraldehyde and stored in 30% glycerol. Freezing was performed either in liquid nitrogen-cooled Freon 22, or directly in a mixture of liquid and solid nitrogen prepared in a special vacuum chamber. The latter method was always used, and considered necessary, when preparations of complementary (double) replicas were made.

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