Increase in lactate dehydrogenase isoenzyme-1 in plasma in pediatric malignancy
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Abstract We investigated 28 cases of pediatric malignancy in which total lactate dehydrogenase (LD, EC 1.1.1.27) activities were increased and isoenzyme LD-1 exceeded LD-2 (flipped pattern). Of these, 11 had a flipped pattern at presentation and 17 showed a flipped pattern during chemotherapy. Those with flipped patterns at presentation were four with germ-cell tumors, one with acute lymphocytic leukemia, and six with nephroblastomas (Wilms tumor). Four of five nephroblastoma homogenates contained predominantly LD-1; one revealed a structurally normal LD-1 with normal kinetics. We conclude that an increase in LD with a flipped pattern is common in nephroblastoma and, in addition, may develop in cancer patients treated with chemotherapy.
2001 ◽
Vol 39
(1)
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1992 ◽
Vol 235
(1)
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pp. 140-146
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1984 ◽
Vol 81
(3)
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pp. 293-296
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1993 ◽
Vol 98
(3)
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pp. 293-298
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2001 ◽
Vol 34
(6)
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pp. 441-454
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