CONTEMPORARY SURVIVAL RESULTS AND THE ROLE OF RADIATION THERAPY IN PATIENTS WITH NODE NEGATIVE SEMINAL VESICLE INVASION FOLLOWING RADICAL PROSTATECTOMY

Aims and Background To determine whether there is a benefit for biochemical control with adjuvant radiation therapy to the surgical bed following radical prostatectomy in patients with seminal vesicle invasion and pathologically negative pelvic lymph nodes (pT3b-pT4 pN0). Methods We retrospectively reviewed the clinical records of radical prostatectomy patients treated between 1995 and 2002. A total of 66 patients with seminal vesicle invasion were identified: 45 of these patients received adjuvant radiation therapy and 21 were observed. Radiation therapy was initiated within 4 months of prostatectomy. Median dose was 66 Gy (range, 60–70 Gy). Median follow-up from the day of surgery was 40.6 months (mean, 41.5; range, 12–99). Biochemical recurrence was defined as the first value ≥0.2 ng/ml. Results At two years, the proportion of patients free from biochemical recurrence was 80% in patients who received adjuvant radiation therapy versus 54% for those not given radiation therapy (P = 0.036). Actuarial biochemical recurrence at 5 years was 59% vs 41% for the radiation therapy and no radiation therapy groups, respectively. On univariate Cox regression model, the hazard of biochemical failure was also associated with a detectable (≥0.2 ng/ml) postsurgical prostate-specific antigen (P = 0.02) prior to radiation therapy. Pathological T stage (pT3b vs pT4), Gleason score, primary Gleason pattern and positive surgical margins were not significantly associated with biochemical recurrence. The hazard of biochemical failure was around 85% lower in the radiation therapy group than in the observation group (P = 0.002). Conclusions Data from the present series suggest that adjuvant radiation therapy for patients with seminal vesicle invasion and undetectable (≤0.2 ng/ml) postoperative prostate-specific antigen significantly reduces the likelihood of biochemical failure.

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Long-term utility of adjuvant hormonal and radiation therapy for patients with seminal vesicle invasion at radical prostatectomy

BJU International ◽

10.1111/bju.13683 ◽

2016 ◽

Vol 120 (1) ◽

pp. 69-75 ◽

Cited By ~ 8

Author(s):

Marco Moschini ◽

Vidit Sharma ◽

Giorgio Gandaglia ◽

Paolo Dell'Oglio ◽

Nicola Fossati ◽

...

Keyword(s):

Radiation Therapy ◽

Radical Prostatectomy ◽

Seminal Vesicle ◽

Seminal Vesicle Invasion

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620 PATHOLOGICAL GLEASON SCORE DICTATES SURVIVAL IN PATIENTS WITH SEMINAL VESICLE INVASION TREATED WITH RADICAL PROSTATECTOMY AND ADJUVANT RADIATION THERAPY. RESULTS FROM A TWO-INSTITUTION SERIES ANALYSIS

European Urology Supplements ◽

10.1016/s1569-9056(10)60609-4 ◽

2010 ◽

Vol 9 (2) ◽

pp. 206

Author(s):

A. Briganti ◽

J. Karnes ◽

N. Suardi ◽

A. Gallina ◽

U. Capitanio ◽

...

Keyword(s):

Radiation Therapy ◽

Radical Prostatectomy ◽

Seminal Vesicle ◽

Gleason Score ◽

Adjuvant Radiation ◽

Adjuvant Radiation Therapy ◽

Seminal Vesicle Invasion ◽

Series Analysis

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SEMINAL VESICLE INVASION: WHAT IS THE BEST ADJUVANT TREATMENT AFTER RADICAL PROSTATECTOMY?

BJU International ◽

10.1111/j.1464-410x.2011.10405.x ◽

2011 ◽

Vol 109 (4) ◽

pp. 531-532

Author(s):

Guillaume Ploussard ◽

Pierre Mongiat-Artus

Keyword(s):

Radical Prostatectomy ◽

Seminal Vesicle ◽

Adjuvant Treatment ◽

Seminal Vesicle Invasion

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1636 DOES LYMPH NODE INVASION IMPACT BIOCHEMICAL RECURRENCE FREE SURVIVAL (BCRFS) FOLLOWING RADICAL PROSTATECTOMY IN MEN WITH SEMINAL VESICLE INVASION?

The Journal of Urology ◽

10.1016/j.juro.2011.02.1745 ◽

2011 ◽

Vol 185 (4S) ◽

Author(s):

Chris Wambi ◽

John Ceccio ◽

Gregory Hruby ◽

Mitchell C. Benson ◽

James M. McKiernan

Keyword(s):

Lymph Node ◽

Radical Prostatectomy ◽

Seminal Vesicle ◽

Biochemical Recurrence ◽

Recurrence Free Survival ◽

Free Survival ◽

Seminal Vesicle Invasion ◽

Invasion Impact

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African-American Race Is a Predictor of Seminal Vesicle Invasion After Radical Prostatectomy

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2014.08.012 ◽

2015 ◽

Vol 13 (2) ◽

pp. e65-e72 ◽

Cited By ~ 7

Author(s):

Kosj Yamoah ◽

Amy Walker ◽

Elaine Spangler ◽

Charnita M. Zeigler-Johnson ◽

Bruce Malkowicz ◽

...

Keyword(s):

African American ◽

Radical Prostatectomy ◽

Seminal Vesicle ◽

Seminal Vesicle Invasion ◽

African American Race

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Factors affecting surgical margin positivity in robotic assisted radical prostatectomy

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2017.1.71 ◽

2017 ◽

Vol 89 (1) ◽

pp. 71 ◽

Cited By ~ 3

Author(s):

Mustafa Yuksel ◽

Kaan Karamık ◽

Hakan Anıl ◽

Ekrem Islamoglu ◽

Mutlu Ates ◽

...

Keyword(s):

Radical Prostatectomy ◽

Seminal Vesicle ◽

Gleason Score ◽

Surgical Margin ◽

Factors Affecting ◽

Seminal Vesicle Invasion ◽

Positive Biopsy ◽

Biopsy Core ◽

Robotic Assisted Radical Prostatectomy ◽

Extraprostatic Extension

Objectives: After radical prostatectomy, surgical margin positivity is an important indicator of biochemical recurrence and progression. In our study we want to compare the surgical margin positivity rates for retropubic radical prostatectomy (RRP) and robotic assisted radical prostatectomy (RALP) and investigate the factors affecting surgical margin positivity in RALP. Materials and methods: Data from 78 RRP and 62 RALP patients operated from 2011 May to 2016 March were retrospectively screened. Patients in both groups were compared in terms of age, postop hematocrit reduction, hospital stay, duration of follow-up, surgical margin positivity, biochemical recurrence and oncologic parameters. In RALP group it was searched the relationship between the surgical margin positivity and prostate specific antigen (PSA), positive biopsy core, biopsy Gleason scoring, pathologic stage and Gleason scoring, lymph node positivity, lymphovascular and perineural invasion, extracapsular extension, seminal vesicle invasion, prostate weight. Results: Patients in the RALP group had lower postop hematocrit reduction and shorter hospital stay (p < 0.001). There was no difference in surgical margin positivity between RALP and RRP groups (37.1% vs. 29.5%, p = 0.341). In RALP group there was a correlation between surgical margin positivity and positive biopsy core number (p = 0.011), pathologic stage (p < 0.001) and Gleason score (p < 0.001), EAU risk classification (p = 0.001), seminal vesicle invasion (p = 0.045), extraprostatic extension (p < 0.001). There was no correlation between prostate weight (p = 0.896), PSA (p = 0.220), biopsy Gleason score (p = 0.266), lymph node positivity (p = 0.140), perineural (p = 0.103) and lymphovascular invasion (p = 0.92) with surgical margin positivity. Conclusions: Positive biopsy core number, pathological stage and Gleason score, EAU risk classification, seminal vesicle invasion and extraprostatic extension are correlated with surgical margin positivity in RALP.

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