On the mechanism of action of pepsin

The present status of the mechanism of action of pepsin is summarized, and a mechanism compatible with the hydrolytic, transpeptidation, and isotopic exchange activities of this enzyme is presented.

2012 ◽  
Vol 2012 ◽  
pp. 1-22 ◽  
Author(s):  
U. Plöckinger

This paper outlines the present status of medical therapy of acromegaly. Indications for permanent postoperative treatment, postirradiation treamtent to bridge the interval until remission as well as primary medical therapy are elaborated. Therapeutic efficacy of the different available drugs—somatostatin receptor ligands (SRLs), dopamine agonists, and the GH antagonist Pegvisomant—is discussed, as are the indications for and efficacy of their respective combinations. Information on their mechanism of action, and some pharmakokinetic data are included. Special emphasis is given to the difficulties to define remission criteria of acromegaly due to technical assay problems. An algorithm for medical therapy in acromegaly is provided.


1978 ◽  
Vol 48 ◽  
pp. 175-178 ◽  
Author(s):  
K. J. Johnston
Keyword(s):  

A summary of results for radio astrometry with baselines ≤ 35 km and priorities for future work are given.


2007 ◽  
Author(s):  
Shauna L. Shapiro ◽  
Doug Oman ◽  
Carl E. Thoresen ◽  
Thomas G. Plante ◽  
Tim Flinders

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