Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial

Osamu Nemoto; Nobukazu Hayashi; Yasumi Kitahara; Masutaka Furue; Seiichiro Hojo; Maiko Nomoto; Satoshi Shima;

doi:10.1111/1346-8138.13231

Effect of topical phosphodiesterase 4 inhibitor E6005 on Japanese children with atopic dermatitis: Results from a randomized, vehicle-controlled exploratory trial

The Journal of Dermatology ◽

10.1111/1346-8138.13231 ◽

2015 ◽

Vol 43 (8) ◽

pp. 881-887 ◽

Cited By ~ 20

Author(s):

Osamu Nemoto ◽

Nobukazu Hayashi ◽

Yasumi Kitahara ◽

Masutaka Furue ◽

Seiichiro Hojo ◽

...

Keyword(s):

Atopic Dermatitis ◽

Japanese Children ◽

Phosphodiesterase 4 ◽

Exploratory Trial ◽

Phosphodiesterase 4 Inhibitor

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A Novel Nonsteroidal, Topical Anti-inflammatory, Phosphodiesterase 4 Inhibitor, Crisaborole Ointment, Reduced Pruritus and Signs of Atopic Dermatitis in 2 Phase 3 Studies in Children and Adults

10.1542/peds.141.1_meetingabstract.251 ◽

2018 ◽

Author(s):

Adelaide A. Hebert ◽

Lawrence F. Eichenfield ◽

Mark G. Lebwohl ◽

Amy S. Paller ◽

Eric L. Simpson ◽

...

Keyword(s):

Atopic Dermatitis ◽

Phase 3 ◽

Phosphodiesterase 4 ◽

Anti Inflammatory ◽

Phosphodiesterase 4 Inhibitor

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Application of phosphodiesterase 4 inhibitor for atopic dermatitis

Folia Pharmacologica Japonica ◽

10.1254/fpj.144.154 ◽

2014 ◽

Vol 144 (4) ◽

pp. 154-159

Author(s):

Naoto Ishii ◽

Hisatsugu Wakita ◽

Kazuki Miyazaki ◽

Yasutaka Takase ◽

Osamu Asano ◽

...

Keyword(s):

Atopic Dermatitis ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

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Phase 3 Studies Treating Children and Adult Patients with Mild to Moderate Atopic Dermatitis with Crisaborole Ointment, a Novel, Nonsteroidal, Topical Anti-inflammatory, Phosphodiesterase 4 Inhibitor

10.1542/peds.141.1_meetingabstract.275 ◽

2018 ◽

Author(s):

Amy S. Paller ◽

Wynnis L. Tom ◽

Mark G. Lebwohl ◽

Mark Boguniewicz ◽

Lawrence F. Eichenfield ◽

...

Keyword(s):

Atopic Dermatitis ◽

Adult Patients ◽

Phase 3 ◽

Phosphodiesterase 4 ◽

Anti Inflammatory ◽

Phosphodiesterase 4 Inhibitor

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Crisaborole topical ointment, 2%: A novel, nonsteroidal, topical antiinflammatory, phosphodiesterase 4 inhibitor: Results from two phase 3 studies treating children and adult patients with mild to moderate atopic dermatitis

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2016.02.337 ◽

2016 ◽

Vol 74 (5) ◽

pp. AB86 ◽

Cited By ~ 1

Keyword(s):

Atopic Dermatitis ◽

Adult Patients ◽

Phase 3 ◽

Two Phase ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

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Antipruritic Effect of the Topical Phosphodiesterase 4 Inhibitor E6005 Ameliorates Skin Lesions in a Mouse Atopic Dermatitis Model

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.205542 ◽

2013 ◽

Vol 346 (1) ◽

pp. 105-112 ◽

Cited By ~ 30

Author(s):

Naoto Ishii ◽

Manabu Shirato ◽

Hisashi Wakita ◽

Kazuki Miyazaki ◽

Yasutaka Takase ◽

...

Keyword(s):

Atopic Dermatitis ◽

Skin Lesions ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor ◽

Antipruritic Effect

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Topical E6005/RVT-501, a novel phosphodiesterase 4 inhibitor, for the treatment of atopic dermatitis

Expert Opinion on Investigational Drugs ◽

10.1080/13543784.2017.1397626 ◽

2017 ◽

Vol 26 (12) ◽

pp. 1403-1408 ◽

Cited By ~ 6

Author(s):

Masutaka Furue ◽

Takafumi Kadono ◽

Gaku Tsuji ◽

Takeshi Nakahara

Keyword(s):

Atopic Dermatitis ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

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Clinical anti-inflammatory efficacy of arofylline, a new selective phosphodiesterase-4 inhibitor, in dogs with atopic dermatitis

Veterinary Record ◽

10.1136/vr.145.7.191 ◽

1999 ◽

Vol 145 (7) ◽

pp. 191-194 ◽

Cited By ~ 25

Author(s):

L. Ferrer ◽

J. Alberola ◽

M. Queralt ◽

P. Brazis ◽

R. Rabanal ◽

...

Keyword(s):

Atopic Dermatitis ◽

Phosphodiesterase 4 ◽

Anti Inflammatory ◽

Phosphodiesterase 4 Inhibitor

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Faculty Opinions recommendation of Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: results of a randomized, vehicle-controlled, multicenter clinical trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718458515.793501282 ◽

2014 ◽

Author(s):

Hidehisa Saeki

Keyword(s):

Clinical Trial ◽

Atopic Dermatitis ◽

Adult Patients ◽

Multicenter Clinical Trial ◽

Japanese Adult ◽

Safety And Efficacy ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

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Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor

Acta Dermato Venereologica ◽

10.2340/00015555-2893 ◽

2018 ◽

Vol 98 (5) ◽

pp. 484-489 ◽

Cited By ~ 22

Author(s):

G Yosipovitch ◽

L Gold ◽

M Lebwohl ◽

J Silverberg ◽

A Tallman ◽

...

Keyword(s):

Atopic Dermatitis ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

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Pharmacokinetic disposition of topical phosphodiesterase-4 inhibitor E6005 in patients with atopic dermatitis

Journal of Dermatological Treatment ◽

10.1080/09546634.2018.1530439 ◽

2018 ◽

Vol 30 (5) ◽

pp. 466-470 ◽

Cited By ~ 2

Author(s):

Yasumi Kitahara ◽

Seiichiro Hojo ◽

Maiko Nomoto ◽

Daisuke Onozuka ◽

Masutaka Furue ◽

...

Keyword(s):

Atopic Dermatitis ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitor

Download Full-text