The treatment of refractory atypical bullous pemphigoid with generalized eczema and intense pruritus with Dupilumab

2021 ◽  
Author(s):  
Wei Li ◽  
Suiqing Cai ◽  
Xiaoyong Man

2013 ◽  
Vol 5 (1) ◽  
pp. 31-36
Author(s):  
Kristina Kostić ◽  
Lidija Kandolf Sekulović ◽  
Radoš D. Zečević

Abstract Bullous pemphigoid is an autoimmune blistering disease that predominantly affects elderly persons and rarely children. We present a 12-year-old girl with sudden appearance of tense blisters on an erythematous base on the trunk, neck, hands and legs with intense pruritus. Standard laboratory test results were within the normal range except for blood eosinophilia of 12% of the total white cell count. Skin biopsy specimens showed evolving subepidermal blisters with perivascular lymphohistiocytic, eosinophil and neutrophil infiltrations in the papillary dermis. Direct immunofluorescence of perilesional skin showed linear, continuous deposits of IgG and C3 along the dermoepidermal junction. Indirect immunofluorescence showed circulating anti-basement membrane zone IgG autoantibodies at a titer of 1:80. We started treatment with systemic corticosteroids, methylprednisolone 0,5 mg/kg per day and 500 mg erythromycin 4 times a day during 10 days. After 3 days 50 mg dapsone (DDS, 4,4-diaminodiphenylsulphone) per day was added. After a few days, there were no new changes on the skin and pruritus disappeared completely.



1998 ◽  
Vol 138 (3) ◽  
pp. 547-548 ◽  
Author(s):  
Yamazaki ◽  
Yokozeki ◽  
Katayama ◽  
Komai ◽  
Hashimoto ◽  
...  


1998 ◽  
Vol 37 (12) ◽  
pp. 940-942 ◽  
Author(s):  
Trevor W. Beer ◽  
Harvey R. Smith ◽  
. Mbbs


1971 ◽  
Vol 103 (5) ◽  
pp. 486-491 ◽  
Author(s):  
R. E. Jordon
Keyword(s):  


1970 ◽  
Vol 101 (6) ◽  
pp. 690-691 ◽  
Author(s):  
M. J. Tye


1980 ◽  
Vol 116 (2) ◽  
pp. 157a-158
Author(s):  
J. Civatte
Keyword(s):  




1977 ◽  
Vol 113 (8) ◽  
pp. 1121-1121 ◽  
Author(s):  
A. R. Ahmed
Keyword(s):  


1980 ◽  
Vol 116 (5) ◽  
pp. 555-556 ◽  
Author(s):  
C. Nieboer


1977 ◽  
Vol 113 (12) ◽  
pp. 1693-1695 ◽  
Author(s):  
K. G. Heine
Keyword(s):  


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