Synthesis and application of acid labile anchor groups for the synthesis of peptide amides by Fmoc-solid-phase peptide synthesis

2009 ◽  
Vol 34 (4) ◽  
pp. 262-267 ◽  
Author(s):  
GERHARD BREIPOHL ◽  
JOCHEN KNOLLE ◽  
WERNER STÜBER
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Acid Labile

Synthesis and Solid-Phase Application of a 9-Xanthenyl Handle

2001 ◽  
Vol 56 (6) ◽  
pp. 526-532 ◽  
Author(s):  
Csaba Somlai ◽  
Péter Hegyes ◽  
Róbert Fenyö ◽  
Gábor K. Tóth ◽  
Botond Penke ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Cell Receptor ◽  
Valeric Acid ◽  
Receptor Complex ◽  
Acid Labile

AbstractThe acid-labile 5-[(9-aminoxanthen-2-yl)oxy]valeric acid was prepared in a six-step route. The usefulness of the resulting handle was investigated with solid-phase peptide synthesis of cholecystokinin-8 sulfate and the phosphorylated fragment of the ζ-subunit of the T-cell receptor complex 138-144.

scholarly journals Tetrahydropyranyl: A Non-aromatic, Mild-Acid-Labile Group for Hydroxyl Protection in Solid-Phase Peptide Synthesis

ChemistryOpen ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Anamika Sharma ◽  
Iván Ramos-Tomillero ◽  
Ayman El-Faham ◽  
Hortensia Rodríguez ◽  
Beatriz G. de la Torre ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Acid Labile ◽  
Mild Acid ◽  
Labile Group
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