Role of KATPChannels in Cephalic Vasodilatation Induced by Calcitonin Gene-Related Peptide, Nitric Oxide, and Transcranial Electrical Stimulation in the Rat

2008 ◽  
Vol 48 (8) ◽  
pp. 1202-1213 ◽  
Author(s):  
Aydin Gozalov ◽  
Inger Jansen-Olesen ◽  
Dan Klaerke ◽  
Jes Olesen
Keyword(s):  
Nitric Oxide ◽  
Electrical Stimulation ◽  
Calcitonin Gene Related Peptide ◽  
Transcranial Electrical Stimulation ◽  
Related Peptide ◽  
Calcitonin Gene

Role of BKCa Channels in Cephalic Vasodilation Induced by CGRP, NO and Transcranial Electrical Stimulation In The Rat

Cephalalgia ◽  
2007 ◽  
Vol 27 (10) ◽  
pp. 1120-1127 ◽  
Author(s):  
A Gozalov ◽  
I Jansen-Olesen ◽  
D Klaerke ◽  
J Olesen
Keyword(s):  
Nitric Oxide ◽  
Electrical Stimulation ◽  
Selective Inhibitor ◽  
Transcranial Electrical Stimulation ◽  
Bkca Channels ◽  
No Donor ◽  
Calcitonin Gene

Both calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are potent vasodilators that have been shown to induce headache in migraine patients. Their antagonists are effective in the treatment of migraine attacks. In the present study, we hypothesize that vasodilation induced by the NO donor glyceryltrinitrate (GTN) or by CGRP is partially mediated via large conductance calcium-activated potassium (BKCa) channels. The effects of the BKCa channel selective inhibitor iberiotoxin on dural and pial vasodilation induced by CGRP, GTN and endogenously released CGRP by transcranial electrical stimulation (TES) were examined. Iberiotoxin significantly attenuated GTN-induced dural and pial artery dilation in vivo and in vitro, but had no effect on vasodilation induced by CGRP and TES. Our results show that GTN- but not CGRP-induced dural and pial vasodilation involves opening of BKCa channels in rat.

Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat

1993 ◽  
Vol 104 (5) ◽  
pp. 1371-1380 ◽  
Author(s):  
Nils Lambrecht ◽  
Maria Burchert ◽  
Michael Respondek ◽  
Klaus-Michael Müller ◽  
Brigitta M. Peskar
Keyword(s):  
Nitric Oxide ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Gastroprotective Effect ◽  
Calcitonin Gene

The Role of Calcitonin Gene-Related Peptide and Nitric Oxide in Gastric Mucosal Hyperemia and Protection

1995 ◽  
Vol 58 (3) ◽  
pp. 344-350 ◽  
Author(s):  
Nipun B. Merchant ◽  
Jay Goodman ◽  
Daniel T. Dempsey ◽  
Richard E. Milner ◽  
Wallace P. Ritchie
Keyword(s):  
Nitric Oxide ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene
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